Evidence map›Paper›PMID 36071172›Full record

SynthesisNature genetics2022

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.

Zhe Wang, Andrew Emmerich, Nicolas J Pillon, Tim Moore, Daiane Hemerich, Marilyn C Cornelis, Eugenia Mazzaferro, Siacia Broos, Tarunveer S Ahluwalia, Traci M Bartz and 209 more

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 5 pooled it
42.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 5 syntheses or guidelines pooled it, 225 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Article
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  12. Are There Causal Associations Between Obsessive-Compulsive Disorder and Cardiometabolic Phenotypes? A Genetic Correlation and Bi-Directional Mendelian Randomization Study.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2026
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  18. Review
  19. Observational
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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

219 authors at 20 institutions in 22 countries.

Zhe WangThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. zhe.wang@mssm.edu.ORCID http://orcid.org/0000-0002-8046-4969
Andrew EmmerichDepartment of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-0908-9924
Nicolas J PillonDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-1107-9490
Tim MooreDivision of Cardiology, Department of Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4250-3370
Daiane HemerichThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marilyn C CornelisDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Eugenia MazzaferroThe Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden.
Siacia BroosFaculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Exercise Physiology Research Group, KU Leuven, Leuven, Belgium.
Tarunveer S AhluwaliaSteno Diabetes Center Copenhagen, Herlev, Denmark.
Traci M BartzCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Amy R BentleyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Mike ChongDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Audrey Y ChuDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Diane BerryDivision of Population, Policy and Practice, Great Ormond Street Hospital Institute for Child Health, University College London, London, UK.
Rajkumar DorajooGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Nicole D DuekerJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Elisa KasbohmInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Bjarke FeenstraDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany.
Mariaelisa GraffDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Leanne M HallDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Toomas HallerEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Fernando P HartwigPostgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
David A HillisGenetics, Genomics, and Bioinformatics Graduate Program, University of California, Riverside, CA, USA.
Ville HuikariInstitute of Health Sciences, University of Oulu, Oulu, Finland.
Nancy Heard-CostaFramingham Heart Study, Framingham, MA, USA.
Christina HolzapfelResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany.
Anne U JacksonDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Åsa JohanssonDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Anja Moltke JørgensenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Marika A KaakinenSection of Statistical Multi-omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK.
Robert KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kathleen F KerrDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Boram KimInterdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea.
Chantal M KoolhaasDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Zoltan KutalikUniversity Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.
Vasiliki LagouWellcome Sanger Institute, Cambridge, UK.
Penelope A LindMental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Mattias LorentzonGeriatric Medicine, Institute of Medicine, University of Gothenburg and Sahlgrenska University Hospital Mölndal, Gothenburg, Sweden.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
Christoph MetzendorfThe Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden.
Kristine R MonroeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Alexander PacoletFaculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Exercise Physiology Research Group, KU Leuven, Leuven, Belgium.
Louis PérusseDepartment of Kinesiology, Université Laval, Quebec, Quebec, Canada.
Rene PoolDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
Rebecca C RichmondMRC Integrative Epidemiology Unit and Avon Longitudinal Study of Parents and Children, University of Bristol Medical School, Population Health Sciences and Avon Longitudinal Study of Parents and Children, University of Bristol, Bristol, UK.
Natalia V RiveraRespiratory Division, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Sebastien Robiou-du-PontDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Katharina E SchrautCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Christina-Alexandra SchulzDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Heather M StringhamDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Constance TurmanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Mathias VanmunsterFaculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Exercise Physiology Research Group, KU Leuven, Leuven, Belgium.
Frank J A van RooijDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Jana V van Vliet-OstaptchoukDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Xiaoshuai ZhangMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Jing-Hua ZhaoDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Zhanna BalkhiyarovaDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Marie N Balslev-HarderNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Sebastian E BaumeisterInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
John BeilbyDiagnostic Genomics, PathWest Laboratory Medicine WA, Perth, Western Australia, Australia.
John BlangeroSouth Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX, USA.
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
Soren BrageMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Peter S BraundDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Marcel BruinenbergLifelines Cohort Study, Groningen, the Netherlands.
Ulf EkelundDepartment of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway.
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
John W ColeVascular Neurology, Department of Neurology, University of Maryland School of Medicine and the Baltimore VAMC, Baltimore, MD, USA.
Francis S CollinsCenter for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
L Adrienne CupplesFramingham Heart Study, Framingham, MA, USA.
Tõnu EskoEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Stefan EnrothDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Lindsay Fernandez-RhodesDepartment of Biobehavioral Health, College of Health and Human Development, Pennsylvania State University, University Park, PA, USA.
Alison E FohnerDepartment of Epidemiology, Institute of Public Health Genetics, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Oscar H FrancoDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Tessel E GaleslootRadboud Institute for Health Sciences, Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands.
Scott D GordonMental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Catharina A HartmanInterdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Gerardo HeissDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Jennie HuiDiagnostic Genomics, PathWest Laboratory Medicine WA, Perth, Western Australia, Australia.
Thomas IlligHannover Unified Biobank, Hannover Medical School, Hannover, Germany.
Russell JagoCentre for Exercise Nutrition & Health Sciences, School for Policy Studies, University of Bristol, Bristol, UK.
Alan JamesDepartment of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Western Australia, Perth, Australia.
Peter K JoshiCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Taeyeong JungInterdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea.
Mika KähönenFinnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Tuomas O KilpeläinenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Woon-Puay KohHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Ivana KolcicDepartment of Public Health, University of Split School of Medicine, Split, Croatia.
Peter P KraftDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Johanna KuusistoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institutes of Health, Baltimore, MD, USA.
Aihua LiDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Allan LinnebergCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Pedro Marques VidalDivision of Internal Medicine, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Sarah E MedlandMental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Yuri MilaneschiDepartment of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.
Arden MoscatiThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bill MuskBusselton Population Medical Research Institute, Busselton, Western Australia, Australia.
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Christine PowerDivision of Population, Policy and Practice, Great Ormond Street Hospital Institute for Child Health, University College London, London, UK.
Olli T RaitakariCentre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Mägi ReedikEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Alex P ReinerDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Igor RudanCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Kathy RyanDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Mark A SarzynskiDepartment of Exercise Science, University of South Carolina, Columbia, SC, USA.
Laura J ScottDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Robert A ScottMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Stephen SidneyDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Kristin SiggeirsdottirIcelandic Heart Association, Kópavogur, Iceland.
Albert V SmithDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Emily SonestedtDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Marin StrømDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
E Shyong TaiSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Koon K TeoDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Barbara ThorandInstitute of Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany.
Anke TönjesDepartment of Medicine, University of Leipzig, Leipzig, Germany.
Angelo TremblayDepartment of Kinesiology, Université Laval, Quebec, Quebec, Canada.
Andre G UitterlindenDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Jagadish VangipurapuInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Natasja van SchoorDepartment of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, the Netherlands.
Uwe VölkerGerman Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.
Gonneke WillemsenDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
Kayleen WilliamsDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Quenna WongDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Huichun XuDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Kristin L YoungDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Jian Min YuanDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
M Carola ZillikensDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Alan B ZondermanLaboratory of Epidemiology and Population Science, National Instiute on Aging, National Institutes of Health, Bethesda, MD, USA.
Adam AmeurDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0001-6085-6749
Stefania BandinelliGeriatric Unit, Azienda USL Toscana Centro, Florence, Italy.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3409-1110
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6442-7754
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.ORCID http://orcid.org/0000-0002-0048-491X
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3357-0862
George Davey SmithMRC Integrative Epidemiology Unit, NIHR Bristol Biomedical Research Center, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-1407-8314
Eco J C de GeusDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-6022-2666
Louise DeldicqueFaculty of Movement and Rehabilitation Sciences, Institute of Neuroscience, UC Louvain, Louvain-la-Neuve, Belgium.
Marcus DörrGerman Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0001-7471-475X
Michele K EvansLaboratory of Epidemiology and Population Science, National Instiute on Aging, National Institutes of Health, Bethesda, MD, USA.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-6273-1613
Myriam FornageBrown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0677-8158
Caroline FoxGenetics and Pharmacogenomics (GpGx), Merck Research Labs, Boston, MA, USA.
Theodore GarlandDepartment of Evolution, Ecology, and Organismal Biology, University of California, Riverside, Riverside, CA, USA.ORCID http://orcid.org/0000-0002-7916-3552
Vilmundur GudnasonIcelandic Heart Association, Kópavogur, Iceland.
Ulf GyllenstenDepartment of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-6316-3355
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8748-3831
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Bernardo L HortaPostgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.ORCID http://orcid.org/0000-0001-9843-412X
Elina HyppönenAustralian Centre for Precision Health, Unit of Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0003-3670-9399
Marjo-Riitta JarvelinInstitute of Health Sciences, University of Oulu, Oulu, Finland.
W Craig JohnsonDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3161-3753
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Lambertus A KiemeneyRadboud Institute for Health Sciences, Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID http://orcid.org/0000-0002-2368-1326
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.ORCID http://orcid.org/0000-0002-3394-7749
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5017-7344
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.ORCID http://orcid.org/0000-0002-2555-4427
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA.
Lifelines Cohort Study
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7315-7899
Nicholas G MartinMental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-4069-8020
Mads MelbyeDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8264-6785
Andres MetspaluEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-3718-796X
David MeyreDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0003-4850-7444
Kari E NorthDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-8903-0366
Claes OhlssonCentre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-9633-2805
Albertine J OldehinkelInterdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0003-3925-3913
Marju Orho-MelanderDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0002-3578-2503
Guillaume PareDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0002-6795-4760
Taesung ParkInterdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea.ORCID http://orcid.org/0000-0002-8294-590X
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-3321-3972
Brenda W J H PenninxDepartment of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.
Tune H PersNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-0207-4831
Ozren PolasekUniversity of Split School of Medicine, Split, Croatia.ORCID http://orcid.org/0000-0002-5765-1862
Inga ProkopenkoDepartment of Clinical and Experimental Medicine, University of Surrey, Guilford, UK.ORCID http://orcid.org/0000-0003-1624-7457
Charles N RotimiCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-5759-053X
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Xueling SimSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-1233-7642
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0003-1949-2298
Thorkild I A SørensenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4821-430X
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, Kings College London, London, UK.ORCID http://orcid.org/0000-0002-9795-0365
Nicholas J TimpsonMRC Integrative Epidemiology Unit, University of Bristol Medical School, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-7141-9189
Rob M van DamSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Nathalie van der VeldeDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Peter VollenweiderDivision of Internal Medicine, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Trudy VoortmanDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-2830-6813
Gérard WaeberDivision of Internal Medicine, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-4193-788X
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1422-2993
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-1661-2402
Heinz-Erich WichmannInstitute of Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany.
James F WilsonCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5751-9178
Andrea L HevenerDivision of Endocrinology, Department of Medicine, University of California, Los Angeles, CA, USA.
Anna KrookDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-0891-0258
Juleen R ZierathDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-6891-7497
Martine A I ThomisFaculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Physical Activity, Sports & Health Research Group, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-9093-2191
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8532-5087
Marcel den HoedThe Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden. marcel.den_hoed@igp.uu.se.ORCID http://orcid.org/0000-0001-8081-428X
University Medical Center Groningen · NLUniversity of Copenhagen · DKUniversity of Michigan · USUniversity of Washington · USUppsala University · SEErasmus MC · NLUniversity of Cambridge · GBUniversitätsmedizin Greifswald · DEAmsterdam University Medical Centers · NLHelmholtz Zentrum München · DEKarolinska Institutet · SENational Institutes of Health · USUniversity of North Carolina at Chapel Hill · USImpact · CAUniversity of Leicester · GBUniversity of Maryland, Baltimore · USBoston University · USBrigham and Women's Hospital · USKU Leuven · BESeoul National University · KR

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Cell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
$13.1M
Polygenic Risk Scores for Diverse Populations - Bridging Research and Clinical CareR01HL151152 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Christy Leigh Avery, Jennifer Below · 2020 to 2026
$12.3M
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Leveraging multi-omics approaches to examine metabolic challenges of obesity in relation to cardiovascular diseasesR01HL143885 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AVERY, CHRISTY LEIGH, GORDON-LARSEN, PENNY · 2019 to 2022
$8.9M
Identifying Genes for Type 2 Diabetes:FUSIONR01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2003 to 2025
$6.7M
PAGE III: Population Architecture using Genomics and EpidemiologyR01HG010297 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI GIGNOUX, CHRISTOPHER R, MATISE, TARA C. · 2019 to 2022
$6.5M
Gene-Environment Interactions and Weight GainR01HD057194 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GORDON-LARSEN, PENNY, NORTH, KARI E. · 2008 to 2019
$5.9M
British Heart Foundation CH/12/2/29428British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946British Heart Foundation SP/16/4/32697Cancer Research UK 29019Cancer Research UK C18281/A19169Department of Health BRC-1215-2001Department of Health BRC-1215-20010Medical Research Council MC_UU_00006/1Medical Research Council MC_UU_00006/4Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_00011NCI NIH HHS U01 CA164973NCI NIH HHS UM1 CA182876NHGRI NIH HHS R01 HG009974NHGRI NIH HHS R01 HG010297NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL142302NHLBI NIH HHS R01 HL143885NHLBI NIH HHS R01 HL149683NHLBI NIH HHS R01 HL151152NIA NIH HHS U01 AG070959NICHD NIH HHS R01 HD057194NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01 DK089256NIDDK NIH HHS R01 DK101855NIDDK NIH HHS R01 DK107786NIDDK NIH HHS R01 DK110113NIDDK NIH HHS R01 DK117850NIDDK NIH HHS R01 DK122503NIDDK NIH HHS R01 DK124097NIDDK NIH HHS U01 DK062370NIEHS NIH HHS P30 ES007033NINDS NIH HHS R01 NS100178NINDS NIH HHS R01 NS105150NINDS NIH HHS R01 NS114045Wellcome TrustWellcome Trust 202802/Z/16/ZWellcome Trust 217065/Z/19/Z
6 · The paper itself

Abstract

Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type II

Indexed as

Genome-Wide Association StudySedentary BehaviorActininCross-Sectional StudiesExerciseHumansLeisure ActivitiesActininACTN3 protein, human

Identifiers

PMID36071172
PMCPMC9470530
OpenAlexW4294904260

What Socratic holds

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