Evidence map›Paper›PMID 36072483›Full record

ArticleFrontiers in aging neuroscience2022

Repurposing food molecules as a potential BACE1 inhibitor for Alzheimer's disease.

Nobendu Mukerjee, Anubhab Das, Rahul D Jawarkar, Swastika Maitra, Padmashree Das, Melvin A Castrosanto, Soumyadip Paul, Abdul Samad, Magdi E A Zaki, Sami A Al-Hussain and 13 more

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 13 institutions in 7 countries.

Nobendu MukerjeeDepartment of Microbiology, Ramakrishna Mission Vivekananda Centenary College, Khardaha, India.
Anubhab DasInstitute of Health Sciences, Presidency University, Kolkata, India.
Rahul D JawarkarDepartment of Medicinal Chemistry, Dr. Rajendra Gode Institute of Pharmacy, Amravati, India.
Swastika MaitraDepartment of Microbiology, Adamas University, Kolkata, India.
Padmashree DasCentral Silk Board, Guwahati, India.
Melvin A CastrosantoInstitute of Chemistry, University of the Philippines Los Baños, Los Baños, Philippines.
Soumyadip PaulDepartment of Microbiology, Ramakrishna Mission Vivekananda Centenary College, Khardaha, India.
Abdul SamadDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tishk International University, Erbil, Iraq.
Magdi E A ZakiDepartment of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia.
Sami A Al-HussainDepartment of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia.
Vijay H MasandDepartment of Chemistry, Vidya Bharati Mahavidyalaya, Amravati, India.
Mohammad Mehedi HasanDepartment of Biochemistry and Molecular Biology, Faculty of Life Sciences, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh.
Syed Nasir Abbas BukhariDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.
Asma PerveenGlocal School of Life Sciences, Glocal University, Saharanpur, India.
Badrah S AlghamdiDepartment of Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Athanasios AlexiouDepartment of Science and Engineering, Novel Global Community Educational Foundation, Hebersham, NSW, Australia.
Mohammad Amjad KamalInstitutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Abhijit DeyDepartment of Life Sciences, Presidency University, Kolkata, India.
Sumira MalikAmity Institute of Biotechnology, Amity University, Jharkhand, Ranchi, India.
Ravindra L BakalDepartment of Medicinal Chemistry, Dr. Rajendra Gode Institute of Pharmacy, Amravati, India.
Adel Mohammad AbuzenadahKing Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Arabinda GhoshMicrobiology Division, Department of Botany, Gauhati University, Guwahati, India.
Ghulam Md AshrafPre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
King Abdulaziz University · SAImam Mohammad ibn Saud Islamic University · SAPresidency University · INSant Gadge Baba Amravati University · INAdamas University · INAl Jouf University · SACentral Silk Technological Research Institute · INDaffodil International University · BDGauhati University · INGlocal University · INMawlana Bhashani Science and Technology University · BDTishk International University · IQUniversity of the Philippines Los Baños · PH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a severe neurodegenerative disorder of the brain that manifests as dementia, disorientation, difficulty in speech, and progressive cognitive and behavioral impairment. The emerging therapeutic approach to AD management is the inhibition of β-site APP cleaving enzyme-1 (BACE1), known to be one of the two aspartyl proteases that cleave β-amyloid precursor protein (APP). Studies confirmed the association of high BACE1 activity with the proficiency in the formation of β-amyloid-containing neurotic plaques, the characteristics of AD. Only a few FDA-approved BACE1 inhibitors are available in the market, but their adverse off-target effects limit their usage. In this paper, we have used both ligand-based and target-based approaches for drug design. The QSAR study entails creating a multivariate GA-MLR (Genetic Algorithm-Multilinear Regression) model using 552 molecules with acceptable statistical performance (

Indexed as

Alzheimer’s diseaseBACE1beta-site APP cleaving enzyme 1glioblastomagolden lotus bananaMD simulationsmolecular dockingQSAR

Identifiers

PMID36072483
PMCPMC9443073
OpenAlexW4292615794

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.