Evidence map›Paper›PMID 36072861›Full record

ArticleFrontiers in cardiovascular medicine2022

Isoprenaline modified the lipidomic profile and reduced β-oxidation in HL-1 cardiomyocytes:

Ivana Fiserova, Minh Duc Trinh, Moustafa Elkalaf, Lukas Vacek, Marek Heide, Stanislava Martinkova, Kamila Bechynska, Vit Kosek, Jana Hajslova, Ondrej Fiser and 2 more

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In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Ivana FiserovaDepartment of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czechia.
Minh Duc TrinhDepartment of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czechia.
Moustafa ElkalafDepartment of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czechia.
Lukas VacekDepartment of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czechia.
Marek HeideDepartment of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czechia.
Stanislava MartinkovaDepartment of Biochemistry, Cell and Molecular Biology, Third Faculty of Medicine, Charles University, Prague, Czechia.
Kamila BechynskaDepartment of Food Analysis and Nutrition, University of Chemistry and Technology Prague, Prague, Czechia.
Vit KosekDepartment of Food Analysis and Nutrition, University of Chemistry and Technology Prague, Prague, Czechia.
Jana HajslovaDepartment of Food Analysis and Nutrition, University of Chemistry and Technology Prague, Prague, Czechia.
Ondrej FiserDepartment of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, Prague, Czechia.
Petr TousekDepartment of Cardiology, Third Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, Prague, Czechia.
Jan PolakDepartment of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czechia.
Charles University · CZUniversity of Chemistry and Technology, Prague · CZUniversity Hospital Kralovske Vinohrady · CZCzech Technical University in Prague · CZUniversity of Hradec Králové · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have suggested a pathogenetic link between impaired mitochondria and Takotsubo syndrome (TTS), which is closely connected with catecholamine overstimulation, poor outcomes, and changes in lipid metabolism. We investigated the changes in lipid metabolism at the level of fatty acid β-oxidation and changes in the intracellular lipidomic spectrum. The immortalized cell line of HL-1 cardiomyocytes was used in this study as an established

Indexed as

cardiomyocytefatty acidisoprenalinelipidmetabolismmitochondriatakotsubo

Identifiers

PMID36072861
PMCPMC9441769
OpenAlexW4292553317

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.