Evidence map›Paper›PMID 36073009›Full record

ArticleEuropean journal of immunology2022

Termination of CD40L co-stimulation promotes human B cell differentiation into antibody-secreting cells.

Casper Marsman, Niels Jm Verstegen, Marij Streutker, Tineke Jorritsma, Louis Boon, Anja Ten Brinke, S Marieke van Ham

Open access · hybridAbstract read
In one paragraph

Article in European journal of immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Casper MarsmanSanquin Research, Department of Immunopathology, University of Amsterdam, Amsterdam, The Netherlands.
Niels Jm VerstegenSanquin Research, Department of Immunopathology, University of Amsterdam, Amsterdam, The Netherlands.
Marij StreutkerSanquin Research, Department of Immunopathology, University of Amsterdam, Amsterdam, The Netherlands.
Tineke JorritsmaSanquin Research, Department of Immunopathology, University of Amsterdam, Amsterdam, The Netherlands.
Louis BoonJJP Biologics, Warsaw, Poland.
Anja Ten BrinkeSanquin Research, Department of Immunopathology, University of Amsterdam, Amsterdam, The Netherlands.
S Marieke van HamSanquin Research, Department of Immunopathology, University of Amsterdam, Amsterdam, The Netherlands.
University of Amsterdam · NLAmsterdam Neuroscience · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human naïve B cells are notoriously difficult to differentiate into antibody-secreting cells (ASCs) in vitro while maintaining sufficient cell numbers to evaluate the differentiation process. B cells require T follicular helper (T

Indexed as

CD40 LigandNF-kappa BB-LymphocytesCell DifferentiationGerminal CenterHumansT-Lymphocytes, Helper-InducerCD40 LigandNF-kappa BCD40Lhuman B cellsIL-21phospho-signalingtranscriptional regulation

Identifiers

PMID36073009
PMCPMC9825913
OpenAlexW4294992189

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.