Evidence map›Paper›PMID 36073935›Full record

ArticleInfection and immunity2022

Legionella pneumophila Cas2 Promotes the Expression of Small Heat Shock Protein C2 That Is Required for Thermal Tolerance and Optimal Intracellular Infection.

Jackson A Campbell, Nicholas P Cianciotto

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Expression of the VapD protein byMicrobiology (Reading, England) · 2026
    Article
  3. mBio · 2025
    Article
  4. Quantitative microbial risk assessment ofNew microbes and new infections · 2025
    Article
  5. Journal of bacteriology · 2024
    Review
  6. Article
  7. Article
  8. Protein sociology of ProA, Mip and other secreted virulence factors at theFrontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jackson A CampbellDepartment of Microbiology and Immunology, Northwestern University Medical School, Chicago, Illinois, USA.
Nicholas P CianciottoDepartment of Microbiology and Immunology, Northwestern University Medical School, Chicago, Illinois, USA.
Northwestern University · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
TR&D 7: Cell Specific ProteomicsP41GM108569 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2015 to 2024
$13.6M
Siderophores of Legionella pneumophilaR01AI139054 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CIANCIOTTO, NICHOLAS P · 2018 to 2021
$1.8M
The non-canonical role of the CRISPR Cas2 nuclease in infection by Legionella pneumophilaR21AI123462 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CIANCIOTTO, NICHOLAS P · 2017 to 2018
$417k
NCI NIH HHS P30 CA060553NIAID NIH HHS R01 AI139054NIAID NIH HHS R21 AI123462NIGMS NIH HHS P41 GM108569
6 · The paper itself

Abstract

Previously, we demonstrated that Cas2 encoded within the CRISPR-Cas locus of Legionella pneumophila strain 130b promotes the ability of the

Indexed as

Acanthamoeba castellaniiHeat-Shock Proteins, SmallLegionella pneumophilaBacterial ProteinsHumansRibonucleasesBacterial ProteinsHeat-Shock Proteins, SmallRibonucleasesCas2CRISPR-Casintracellular infectionLegionella pneumophilasmall heat shock proteinthermal tolerance

Identifiers

PMID36073935
PMCPMC9584283
OpenAlexW4294956043

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.