Evidence map›Paper›PMID 36075929›Full record

ArticleNature communications2022

Germline-somatic JAK2 interactions are associated with clonal expansion in myelofibrosis.

Derek W Brown, Weiyin Zhou, Youjin Wang, Kristine Jones, Wen Luo, Casey Dagnall, Kedest Teshome, Alyssa Klein, Tongwu Zhang, Shu-Hong Lin and 21 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Homozygosity of germ lineBlood neoplasia · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 6 institutions in 2 countries.

Derek W BrownDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. derek.brown@nih.gov.ORCID 0000-0001-8393-1713
Weiyin ZhouDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Youjin WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Kristine JonesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Wen LuoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Casey DagnallDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0001-7334-4718
Kedest TeshomeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Alyssa KleinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0003-3763-5731
Tongwu ZhangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0003-2124-2706
Shu-Hong LinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Olivia W LeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Sairah KhanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0003-4769-0654
Jacqueline B VoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Amy HutchinsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Jia LiuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Jiahui WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Bin ZhuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Belynda HicksDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0001-8014-4888
Andrew St MartinCenter for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI, USA.
Stephen R SpellmanCenter for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, MN, USA.ORCID 0000-0002-7271-8252
Tao WangCenter for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI, USA.
H Joachim DeegClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Vikas GuptaMPN Program, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-1419-8607
Stephanie J LeeCenter for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0003-2600-6390
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Meredith YeagerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0003-3871-2225
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0002-2324-3393
Sharon A SavageDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0001-6006-0740
Wael SaberCenter for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI, USA.
Shahinaz M GadallaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. mitchell.machiela@nih.gov.ORCID 0000-0001-6538-9705
National Cancer Institute · USFrederick National Laboratory for Cancer Research · USMedical College of Wisconsin · USFred Hutch Cancer Center · USNational Marrow Donor Program · USUniversity of Toronto · CA

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
British Heart FoundationMedical Research Council MC_PC_17228Medical Research Council MC_QA137853NCI NIH HHS U24 CA076518Wellcome Trust
6 · The paper itself

Abstract

Myelofibrosis is a rare myeloproliferative neoplasm (MPN) with high risk for progression to acute myeloid leukemia. Our integrated genomic analysis of up to 933 myelofibrosis cases identifies 6 germline susceptibility loci, 4 of which overlap with previously identified MPN loci. Virtual karyotyping identifies high frequencies of mosaic chromosomal alterations (mCAs), with enrichment at myelofibrosis GWAS susceptibility loci and recurrently somatically mutated MPN genes (e.g., JAK2). We replicate prior MPN associations showing germline variation at the 9p24.1 risk haplotype confers elevated risk of acquiring JAK2

Indexed as

Myeloproliferative DisordersPrimary MyelofibrosisGerm CellsHaplotypesHumansJanus Kinase 2MutationJAK2 protein, humanJanus Kinase 2

Identifiers

PMID36075929
PMCPMC9458655
OpenAlexW4295004843

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.