ArticleActa neuropathologica communications2022
Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3
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Article in Acta neuropathologica communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
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26 citing papers in PubMed, 39 citations in OpenAlex.
- Retinal proteomics in neurodegeneration: Insights into ocular and brain disorders.Neural regeneration research · 2026Article
- Peripheral and Central miRNA Signatures in Alzheimer's Disease: Tissue-Specific Variability, Sex-Associated Differences, and Implications for Blood-Based Biomarkers.International journal of molecular sciences · 2026Review
- Cadmium causes osteoporosis by osteogenic differentiation inhibition via miR-155/SMAD5 pathway: evidence from in vivo and in vitro studies.Archives of toxicology · 2026Article
- Age-Related Neurovascular Dysfunction in the Retina and Potential Pathogenic Mechanisms.Investigative ophthalmology & visual science · 2026Review
- TREM2 in age-related macular degeneration: a microglia-centered perspective in the retinal myeloid landscape.Frontiers in ophthalmology · 2026Review
- Neuroinflammation in Alzheimer's disease-associated sensory dysfunction: mechanistic links, actionable targets and therapeutic strategies.Frontiers in aging neuroscience · 2026Review
- Single-cell analysis identifies MKI67Journal of translational medicine · 2025Article
- Glial-mediated immune modulation in glaucomatous neurodegeneration: mechanisms and therapeutic implications.Frontiers in immunology · 2025Review
- Polyphenols and miRNA interplay: a novel approach to combat apoptosis and inflammation in Alzheimer's disease.Frontiers in aging neuroscience · 2025Review
- The Dynamic Role of Curcumin in Mitigating Human Illnesses: Recent Advances in Therapeutic Applications.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Candidate SNP Markers Significantly Altering the Affinity of the TATA-Binding Protein for the Promoters of Human Genes Associated with Primary Open-Angle Glaucoma.International journal of molecular sciences · 2024Article
- Mutant mice with rod-specific VPS35 deletion exhibit retinal α-synuclein pathology-associated degeneration.Nature communications · 2024Article
- Alzheimer's disease pathophysiology in the Retina.Progress in retinal and eye research · 2024Review
- miR-199a-5p modulates choroidal neovascularization by regulating Wnt7b/Wnt/β-catenin signaling pathway.Journal of molecular histology · 2024Article
- Loss of 15-Lipoxygenase in Retinodegenerative RCS Rats.International journal of molecular sciences · 2024Article
- Spatial proteomics of hippocampal subfield-specific pathology in Alzheimer's disease and primary age-related tauopathy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- The fluorescent ligand bTVBT2 reveals increased p-tau uptake by retinal microglia in Alzheimer's disease patients and AppAlzheimer's research & therapy · 2024Article
- Exploring galectin-3's role in predicting mild cognitive impairment in type 2 diabetes and its regulation by miRNAs.Frontiers in medicine · 2024Article
- Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
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Authors and funding
18 authors at 6 institutions in 2 countries.
Haoshen ShiDepartment of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, A6212, USA.
Zhuoran YinDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Yosef KoronyoDepartment of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, A6212, USA.
Dieu-Trang FuchsDepartment of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, A6212, USA.
Julia SheynDepartment of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, A6212, USA.
Miyah R DavisDepartment of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, A6212, USA.
Jered W WilsonDepartment of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, A6212, USA.
Milica A MargetaDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kristen M PittsDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Shawn HerronDepartment of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Seiko IkezuDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, USA.
Tsuneya IkezuDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, USA.
Stuart L GrahamDepartment of Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.
Vivek K GuptaDepartment of Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.
Keith L BlackDepartment of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, A6212, USA.
Mehdi MirzaeiDepartment of Molecular Sciences, Macquarie University, Sydney, NSW, Australia.
Oleg ButovskyDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Maya Koronyo-HamaouiDepartment of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, A6212, USA. maya.koronyo@csmc.edu.ORCID 0000-0003-2864-8442
Cedars-Sinai Medical Center · USBrigham and Women's Hospital · USMacquarie University · AUMayo Clinic in Florida · USAGRF Ltd · AUBoston University · US
Funding
Mass Eye and Ear-Vision Clinical Scientist Development ProgramK12EY016335 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Reza Dana · 2004 to 2026
$12.3MTargeting TGFb/IFNy-IRF8 Signaling to Modulate Monocytes and their Crosstalk with Microglia and Astrocytes to Treat Multiple SclerosisR01NS088137 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI Oleg Butovsky · 2014 to 2026
$4.9MAlzheimer's Disease Hallmark Pathology and Associated Inflammation in the RetinaR01AG055865 · NIA · CEDARS-SINAI MEDICAL CENTER · PI Maya Koronyo-Hamaoui · 2018 to 2026
$4.9MTargeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer’s diseaseR01AG054672 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BUTOVSKY, OLEG, IKEZU, TSUNEYA · 2017 to 2021
$4.1MThe role of Chlamydia pneumoniae infection in Alzheimer's DiseaseR01AG075998 · NIA · CEDARS-SINAI MEDICAL CENTER · PI Timothy Robert Crother, Maya Koronyo-Hamaoui · 2021 to 2026
$3.7MSex-dependent APOE4 regulation of neutrophil-microglia crosstalk in Alzheimer's diseaseR01AG075509 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Oleg Butovsky · 2022 to 2026
$3.6MMicroglial mechanisms of postoperative CNS inflammation and cognitive declineR01AG051812 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BUTOVSKY, OLEG, CROSBY, GREGORY · 2016 to 2020
$2.7MCognition and the immunology of postoperative outcomesR01GM132668 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI CULLEY, DEBORAH J · 2019 to 2024
$2.7MRetinal Imaging of Alzheimer's Disease PathologyR01AG056478 · NIA · CEDARS-SINAI MEDICAL CENTER · PI KORONYO-HAMAOUI, MAYA · 2017 to 2021
$2.5MRole of Microglia in Retinitis PigementosaR01EY027921 · NEI · BRIGHAM AND WOMEN'S HOSPITAL · PI BUTOVSKY, OLEG, HAIDER, NEENA B · 2017 to 2019
$1.5MThe Role of APOE Signaling in Microglia in GlaucomaK08EY030160 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI MARGETA, MILICA · 2019 to 2021
$703kIdentification of exosome signature in serum from ALS patientsR21NS104609 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI BERRY, JAMES DALE, BUTOVSKY, OLEG · 2018 to 2019
$543kNEI NIH HHS K08 EY030160NEI NIH HHS K12 EY016335NEI NIH HHS R01 EY027921NIA NIH HHS R01 AG051812NIA NIH HHS R01 AG054672NIA NIH HHS R01 AG055865NIA NIH HHS R01 AG056478NIA NIH HHS R01 AG075509NIA NIH HHS R01 AG075998NIA NIH HHS R21 AG076982NIGMS NIH HHS R01 GM132668NINDS NIH HHS R01 NS088137NINDS NIH HHS R21 NS101673NINDS NIH HHS R21 NS104609
Abstract
Single cell RNA sequencing studies identified novel neurodegeneration-associated microglial (MGnD/DAM) subtypes activated around cerebral amyloid plaques. Micro-RNA (miR)-155 of the TREM2-APOE pathway was shown to be a key transcriptional regulator of MGnD microglial phenotype. Despite growing interest in studying manifestations of Alzheimer's disease (AD) in the retina, a CNS organ accessible to noninvasive high-resolution imaging, to date MGnD microglia have not been studied in the AD retina. Here, we discovered the presence and increased populations of Clec7a
Indexed as
Alzheimer DiseaseMicroRNAsAnimalsDectin-1Disease Models, AnimalGalectin 3InflammationLectins, C-TypeMembrane GlycoproteinsMiceMice, TransgenicMicrogliaPhenotypePhosphatidylinositol 3-KinasesReceptors, ImmunologicClec7a protein, mouseDectin-1Galectin 3Lectins, C-TypeMembrane GlycoproteinsMicroRNAsMirn155 microRNA, mousePhosphatidylinositol 3-KinasesReceptors, ImmunologicTrem2 protein, mouseAlzheimer’s diseaseInflammationMicrogliamicroRNARetinopathyVascular damage
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What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.