Evidence map›Paper›PMID 36077029›Full record

ArticleInternational journal of molecular sciences2022

Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics.

Jay P McLaughlin, Ramanjaneyulu Rayala, Ashley J Bunnell, Mukund P Tantak, Shainnel O Eans, Khadija Nefzi, Michelle L Ganno, Colette T Dooley, Adel Nefzi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jay P McLaughlinDepartment of Pharmacodynamics, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0001-9851-9342
Ramanjaneyulu RayalaCenter for Translational Science, Florida International University, Port St. Lucie, FL 34987, USA.
Ashley J BunnellCenter for Translational Science, Florida International University, Port St. Lucie, FL 34987, USA.
Mukund P TantakCenter for Translational Science, Florida International University, Port St. Lucie, FL 34987, USA.ORCID 0000-0001-9230-7533
Shainnel O EansDepartment of Pharmacodynamics, University of Florida, Gainesville, FL 32610, USA.
Khadija NefziDepartment of Pharmacodynamics, University of Florida, Gainesville, FL 32610, USA.
Michelle L GannoTorrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie, FL 34987, USA.
Colette T DooleyTorrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie, FL 34987, USA.
Adel NefziCenter for Translational Science, Florida International University, Port St. Lucie, FL 34987, USA.
Florida International University · USUniversity of Florida · USTorrey Pines Institute For Molecular Studies · US

Funding

Synthesis and in vitro and in vivo screening of fused and tethered heterocyclic peptidomimetics for the discovery of new analgesics with decreased side effectsR33DA044425 · NIDA · TORREY PINES INST FOR MOLECULAR STUDIES · PI MCLAUGHLIN, JAY P., NEFZI, ADEL · 2020 to 2022
$922k
NIDA NIH HHS R33 DA044425NIDA NIH HHS R33DA044425
6 · The paper itself

Abstract

The design and development of analgesics with mixed-opioid receptor interactions has been reported to decrease side effects, minimizing respiratory depression and reinforcing properties to generate safer analgesic therapeutics. We synthesized bis-cyclic guanidine heterocyclic peptidomimetics from reduced tripeptides. In vitro screening with radioligand competition binding assays demonstrated variable affinity for the mu-opioid receptor (MOR), delta-opioid receptor (DOR), and kappa-opioid receptor (KOR) across the series, with compound

Indexed as

PeptidomimeticsRespiratory InsufficiencyAnalgesicsAnalgesics, OpioidAnimalsGuanidineGuanidinesLigandsMiceReceptors, OpioidReceptors, Opioid, deltaReceptors, Opioid, kappaReceptors, Opioid, muAnalgesicsAnalgesics, OpioidGuanidineGuanidinesLigandsPeptidomimeticsReceptors, OpioidReceptors, Opioid, deltaReceptors, Opioid, kappaReceptors, Opioid, muantinociceptioncombinatorial chemistryheterocyclic peptidomimeticsmultifunctional opioid agonistopioid receptorssolid-phase synthesis

Identifiers

PMID36077029
PMCPMC9455983
OpenAlexW4293103677

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.