Evidence map›Paper›PMID 36077209›Full record

ArticleInternational journal of molecular sciences2022

Genetic Variants of ABC and SLC Transporter Genes and Chronic Myeloid Leukaemia: Impact on Susceptibility and Prognosis.

Raquel Alves, Ana Cristina Gonçalves, Joana Jorge, Gilberto Marques, André B Ribeiro, Rita Tenreiro, Margarida Coucelo, Joana Diamond, Bárbara Oliveiros, Amélia Pereira and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Raquel AlvesLaboratory of Oncobiology and Hematology (LOH), University Clinic of Hematology, Faculty of Medicine University of Coimbra (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0003-2599-6433
Ana Cristina GonçalvesLaboratory of Oncobiology and Hematology (LOH), University Clinic of Hematology, Faculty of Medicine University of Coimbra (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0003-1470-4802
Joana JorgeLaboratory of Oncobiology and Hematology (LOH), University Clinic of Hematology, Faculty of Medicine University of Coimbra (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0003-0755-8077
Gilberto MarquesClinical Pathology Service, Centro Hospitalar e Universitário de Coimbra (CHUC), 3000-061 Coimbra, Portugal.
André B RibeiroCoimbra Institute for Clinical and Biomedical Research (iCBR)-Group of Environmental Genetics of Oncobiology (CIMAGO), Faculty of Medicine University of Coimbra (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0002-5497-2310
Rita TenreiroHematology Service, Centro Hospitalar e Universitário de Coimbra (CHUC), 3000-061 Coimbra, Portugal.
Margarida CouceloCoimbra Institute for Clinical and Biomedical Research (iCBR)-Group of Environmental Genetics of Oncobiology (CIMAGO), Faculty of Medicine University of Coimbra (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.
Joana DiamondHemato-Oncology Laboratory, Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, 1099-023 Lisbon, Portugal.
Bárbara OliveirosCoimbra Institute for Clinical and Biomedical Research (iCBR)-Group of Environmental Genetics of Oncobiology (CIMAGO), Faculty of Medicine University of Coimbra (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0001-7836-8161
Amélia PereiraCoimbra Institute for Clinical and Biomedical Research (iCBR)-Group of Environmental Genetics of Oncobiology (CIMAGO), Faculty of Medicine University of Coimbra (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.
Paulo Freitas-TavaresHematology Service, Centro Hospitalar e Universitário de Coimbra (CHUC), 3000-061 Coimbra, Portugal.ORCID 0000-0001-7832-4134
António M AlmeidaHospital da Luz Lisboa, 1500-650 Lisbon, Portugal.
Ana Bela Sarmento-RibeiroLaboratory of Oncobiology and Hematology (LOH), University Clinic of Hematology, Faculty of Medicine University of Coimbra (FMUC), University of Coimbra, 3000-548 Coimbra, Portugal.ORCID 0000-0002-4142-4841
Hospitais da Universidade de Coimbra · PTUniversity of Coimbra · PTHospital da Luz · PTUniversidade Católica Portuguesa · PT

Funding

Fundação para a Ciência e Tecnologia PO-CI-01-0145-FEDER-007440Fundação para a Ciência e Tecnologia SFRH/BD/51994/2012Fundação para a Ciência e Tecnologia Strategic Projects UID/NEU/04539/2013Fundação para a Ciência e Tecnologia UID/NEU/04539/2019
6 · The paper itself

Abstract

Solute carrier (SLC) and ATP-binding cassette (ABC) transporters comprise a variety of proteins expressed on cell membranes responsible for intrusion or extrusion of substrates, respectively, including nutrients, xenobiotics, and chemotherapeutic agents. These transporters mediate the cellular disposition of tyrosine kinase inhibitors (TKIs), and their genetic variants could affect its function, potentially predisposing patients to chronic myeloid leukaemia (CML) and modulating treatment response. We explored the impact of genetic variability (single nucleotide variants-SNVs) of drug transporter genes (

Indexed as

Antineoplastic AgentsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveATP-Binding Cassette TransportersDrug Resistance, NeoplasmFusion Proteins, bcr-ablGenotypeHumansMembrane Transport ProteinsProtein Kinase InhibitorsSolute Carrier Family 22 Member 5Antineoplastic AgentsATP-Binding Cassette TransportersFusion Proteins, bcr-ablMembrane Transport ProteinsProtein Kinase InhibitorsSLC22A5 protein, humanSolute Carrier Family 22 Member 5cancer predispositionCMLdrug transportersTKI resistance

Identifiers

PMID36077209
PMCPMC9456284
OpenAlexW4293724037

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.