ArticleInternational journal of molecular sciences2022
Dysregulated Metabolic Pathways in Subjects with Obesity and Metabolic Syndrome.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Association between atherogenic index of plasma and various metabolic conditions: an umbrella review on meta-analyses.BMC cardiovascular disorders · 2025Pooled it
- UntargetedNutrients · 2026Trial
- Sanhua Tea Alleviates Obesity Symptoms by Improving Blood Lipid Levels, Gut Microbiota, and Liver Metabolome in Mice.Foods (Basel, Switzerland) · 2026Article
- Multi-Omics Analyses of the Gut Microbiota and Metabolism in Cats with Different Body Conditions and the Effects of Fecal Microbiota Transplantation.Veterinary sciences · 2026Article
- ZJU index and prevalence of kidney stones in US adults: evidence for a threshold association from NHANES 2007-2018.Translational andrology and urology · 2026Article
- Visceral fat metabolism score and cardiovascular-kidney-metabolic syndrome stages in all-cause and cause-specific mortality: insights from UK Biobank.Nutrition & metabolism · 2026Article
- Integrated gut microbiome and serum lipidomics reveals microbial-lipid interactions for predicting incident metabolic syndrome: a nested case-control study.Frontiers in microbiology · 2026Article
- Metabolomic signatures in adults with metabolic syndrome indicate preclinical disruptions in pathways associated with high-density lipoprotein cholesterol, sugar alcohols.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Metabolically Healthy Obesity Is Characterized by a Distinct Proteome Signature.International journal of molecular sciences · 2025Article
- ACSS2 and metabolic diseases: from lipid metabolism to therapeutic target.Lipids in health and disease · 2025Review
- Dysregulated tryptophan metabolism contributes to metabolic syndrome in Chinese community-dwelling older adults.BMC endocrine disorders · 2025Article
- Association between novel anthropometric indices and overactive bladder: a population-based study.Frontiers in nutrition · 2025Article
- Nontargeted and targeted metabolic profile of metabolic syndrome patients: a study based on Yi and Han populations in Yunnan.Frontiers in endocrinology · 2025Article
- Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and kidney stone: evidence from NHANES 2007-2018.BMC public health · 2024Article
- A new framework for exploratory network mediator analysis in omics data.Genome research · 2024Article
- Inflammatory protein signatures in individuals with obesity and metabolic syndrome.Scientific reports · 2023Article
- Amino Acid Metabolism and Disease.International journal of molecular sciences · 2023Article
- An integrated multi-omic approach demonstrates distinct molecular signatures between human obesity with and without metabolic complications: a case-control study.Journal of translational medicine · 2023Article
- Article
- Total flavonoids extracted fromFrontiers in pharmacology · 2023Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Background: Obesity coexists with variable features of metabolic syndrome, which is associated with dysregulated metabolic pathways. We assessed potential associations between serum metabolites and features of metabolic syndrome in Arabic subjects with obesity. Methods: We analyzed a dataset of 39 subjects with obesity only (OBO, n = 18) age-matched to subjects with obesity and metabolic syndrome (OBM, n = 21). We measured 1069 serum metabolites and correlated them to clinical features. Results: A total of 83 metabolites, mostly lipids, were significantly different (p < 0.05) between the two groups. Among lipids, 22 sphingomyelins were decreased in OBM compared to OBO. Among non-lipids, quinolinate, kynurenine, and tryptophan were also decreased in OBM compared to OBO. Sphingomyelin is negatively correlated with glucose, HbA1C, insulin, and triglycerides but positively correlated with HDL, LDL, and cholesterol. Differentially enriched pathways include lysine degradation, amino sugar and nucleotide sugar metabolism, arginine and proline metabolism, fructose and mannose metabolism, and galactose metabolism. Conclusions: Metabolites and pathways associated with chronic inflammation are differentially expressed in subjects with obesity and metabolic syndrome compared to subjects with obesity but without the clinical features of metabolic syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.