Evidence mapPaperPMID 36077337Full record

ArticleInternational journal of molecular sciences2022

Elevated Oxytocin Receptor Blood Concentrations Predict Higher Risk for, More, and Earlier 24-Month Hospital Readmissions after In-Patient Detoxification in Males with Alcohol Use Disorder.

Christiane Mühle, Massimiliano Mazza, Christian Weinland, Claudia von Zimmermann, Patrick Bach, Falk Kiefer, Valery Grinevich, Iulia Zoicas, Johannes Kornhuber, Bernd Lenz

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Christiane MühleDepartment of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Schwabachanlage 6, D-91054 Erlangen, Germany.ORCID 0000-0001-7517-9154
Massimiliano MazzaDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim, Heidelberg University, J 5, D-68159 Mannheim, Germany.ORCID 0000-0001-5143-7198
Christian WeinlandDepartment of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Schwabachanlage 6, D-91054 Erlangen, Germany.
Claudia von ZimmermannDepartment of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Schwabachanlage 6, D-91054 Erlangen, Germany.
Patrick BachDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim, Heidelberg University, J 5, D-68159 Mannheim, Germany.
Falk KieferDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim, Heidelberg University, J 5, D-68159 Mannheim, Germany.
Valery GrinevichDepartment of Neuropeptide Research in Psychiatry, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim, Heidelberg University, J 5, D-68159 Mannheim, Germany.
Iulia ZoicasDepartment of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Schwabachanlage 6, D-91054 Erlangen, Germany.ORCID 0000-0001-7187-3181
Johannes KornhuberDepartment of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Schwabachanlage 6, D-91054 Erlangen, Germany.ORCID 0000-0002-8096-3987
Bernd LenzDepartment of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Schwabachanlage 6, D-91054 Erlangen, Germany.ORCID 0000-0001-6086-0924
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEHeidelberg University · DE

Funding

Deutsche Forschungsgemeinschaft 270949263 / GRK2162Deutsche Forschungsgemeinschaft Project-ID 402170461 - TRR265intramural grants from the University Hospital of the Friedrich-Alexander University Erlan-gen-Nürnberg (FAU intramural grants
6 · The paper itself

Abstract

Alcohol use disorder (AUD) is a major global mental health challenge. Knowledge concerning mechanisms underlying AUD and predictive biomarkers of AUD progression and relapse are insufficient. Recently, addiction research is focusing attention on the oxytocin system. However, to our knowledge, blood concentrations of the oxytocin receptor (OXTR) have not yet been studied in AUD. Here, in sex-separated analyses, OXTR serum concentrations were compared between early-abstinent in-patients with AUD (113 men, 87 women) and age-matched healthy controls (133 men, 107 women). The OXTR concentrations were correlated with sex hormone and oxytocin concentrations and alcohol-related hospital readmissions during a 24-month follow-up. In male patients with AUD, higher OXTR concentrations were found in those with an alcohol-related readmission than in those without (143%;

Indexed as

AlcoholismReceptors, OxytocinEthanolFemaleHumansMaleNeoplasm Recurrence, LocalOxytocinPatient ReadmissionProspective StudiesEthanolOxytocinReceptors, Oxytocinalcohol dependencealcohol relapsealcohol use disorderoxytocin receptor

Identifiers

PMID36077337
PMCPMC9455990
OpenAlexW4294151526

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.