Evidence map›Paper›PMID 36077357›Full record

ArticleInternational journal of molecular sciences2022

Caffeine Inhibits NLRP3 Inflammasome Activation by Downregulating TLR4/MAPK/NF-κB Signaling Pathway in an Experimental NASH Model.

Eduardo E Vargas-Pozada, Erika Ramos-Tovar, Juan D Rodriguez-Callejas, Irina Cardoso-Lezama, Silvia Galindo-Gómez, Daniel Talamás-Lara, Verónica Rocío Vásquez-Garzón, Jaime Arellanes-Robledo, Víctor Tsutsumi, Saúl Villa-Treviño and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
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  7. Luteolin-Rich Extract fromLife (Basel, Switzerland) · 2025
    Article
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  19. Caffeine and neonatal acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Eduardo E Vargas-PozadaLaboratory of Experimental Hepatology, Department of Pharmacology, Cinvestav-IPN, Mexico City 07360, Mexico.ORCID 0000-0002-9601-5893
Erika Ramos-TovarPostgraduate Studies and Research Section, School of Higher Education in Medicine-IPN, Plan de San Luis y Díaz Mirón s/n, Casco de Santo Tomás, Mexico City 11340, Mexico.ORCID 0000-0002-6616-9760
Juan D Rodriguez-CallejasLaboratory of Neuroplasticity and Neurodegeneration, Department of Pharmacology, Cinvestav-IPN, Mexico City 07360, Mexico.
Irina Cardoso-LezamaLaboratory of Experimental Hepatology, Department of Pharmacology, Cinvestav-IPN, Mexico City 07360, Mexico.ORCID 0000-0003-4668-6354
Silvia Galindo-GómezDepartment of Infectomics and Molecular Pathogenesis, Cinvestav-IPN, Mexico City 07360, Mexico.
Daniel Talamás-LaraDepartment of Infectomics and Molecular Pathogenesis, Cinvestav-IPN, Mexico City 07360, Mexico.ORCID 0000-0002-0982-2241
Verónica Rocío Vásquez-GarzónLaboratory of Fibrosis and Cancer, Faculty of Medicine and Surgery, 'Benito Juárez' Autonomous University of Oaxaca, UABJO, Oaxaca 68020, Mexico.ORCID 0000-0002-4861-8235
Jaime Arellanes-RobledoDirectorate of Catedras, National Council of Science and Technology CONACYT, Mexico City 03940, Mexico.ORCID 0000-0001-7363-4870
Víctor TsutsumiDepartment of Infectomics and Molecular Pathogenesis, Cinvestav-IPN, Mexico City 07360, Mexico.
Saúl Villa-TreviñoDepartment of Cell Biology, Cinvestav-IPN, Mexico City 07360, Mexico.
Pablo MurielLaboratory of Experimental Hepatology, Department of Pharmacology, Cinvestav-IPN, Mexico City 07360, Mexico.ORCID 0000-0002-2236-6631
Instituto Politécnico Nacional · MXNational Institute of Genomic Medicine · MXSecretaría de Ciencia, Humanidades, Tecnología e Innovación · MX

Funding

Consejo Nacional de Ciencia y Tecnología 53358Consejo Nacional de Ciencia y Tecnología 724340Consejo Nacional de Ciencia y Tecnología A1-S-27705
6 · The paper itself

Abstract

Caffeine elicits protective effects against liver diseases, such as NASH; however, its mechanism of action involving the pyrin domain-containing-3 (NLRP3) inflammasome signaling pathway remains to be elucidated. This study aimed to evaluate the effect of caffeine on the NLRP3 inflammasome signaling pathway in a rat model of NASH. NASH was induced by feeding rats a high-fat, -sucrose, and -cholesterol diet (HFSCD) for 15 weeks along with a weekly low dose (400 mg/kg, i.p.) of CCl

Indexed as

NF-kappa BNon-alcoholic Fatty Liver DiseaseAnimalsCaffeineInflammasomesMitogen-Activated Protein KinasesNLR Family, Pyrin Domain-Containing 3 ProteinRatsSignal TransductionToll-Like Receptor 4CaffeineInflammasomesMitogen-Activated Protein KinasesNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratTlr4 protein, ratToll-Like Receptor 4caffeineleucine-rich-containing familymitogen-activated protein kinasenon-alcoholic steatohepatitisnuclear factor-κBnucleotide-binding domainpyrin domain-containing-3 inflammasometoll-like receptor 4

Identifiers

PMID36077357
PMCPMC9456282
OpenAlexW4294151194

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.