Evidence map›Paper›PMID 36077501›Full record

ReviewInternational journal of molecular sciences2022

Hormone-Glutamine Metabolism: A Critical Regulatory Axis in Endocrine-Related Cancers.

Fengyuan Xu, Jialu Shi, Xueyun Qin, Zimeng Zheng, Min Chen, Zhi Lin, Jiangfeng Ye, Mingqing Li

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Fengyuan XuDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jialu ShiDepartment of Gynecology, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai 200010, China.
Xueyun QinLaboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai 200080, China.
Zimeng ZhengLaboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai 200080, China.
Min ChenLaboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai 200080, China.
Zhi LinDepartment of Gynecology, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai 200010, China.
Jiangfeng YeInstitute for Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138632, Singapore.
Mingqing LiLaboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai 200080, China.ORCID 0000-0002-9276-0722
Fudan University · CNObstetrics and Gynecology Hospital of Fudan University · CNAgency for Science, Technology and Research · SGUniversity of Pennsylvania · US

Funding

National Natural Science Foundation of China 92057119, 31970798Program for Zhuoxue of Fudan University JIF157602Support Project for Original Personalized Research of Fudan University
6 · The paper itself

Abstract

The endocrine-related cancers and hormones are undoubtedly highly interconnected. How hormones support or repress tumor induction and progression has been extensively profiled. Furthermore, advances in understanding the role of glutamine metabolism in mediating tumorigenesis and development, coupled with these in-depth studies on hormone (e.g., estrogen, progesterone, androgen, prostaglandin, thyroid hormone, and insulin) regulation of glutamine metabolism, have led us to think about the relationship between these three factors, which remains to be elucidated. Accordingly, in this review, we present an updated overview of glutamine metabolism traits and its influence on endocrine oncology, as well as its upstream hormonal regulation. More importantly, this hormone/glutamine metabolism axis may help in the discovery of novel therapeutic strategies for endocrine-related cancer.

Indexed as

Endocrine Gland NeoplasmsNeoplasmsEndocrine SystemGlutamineHumansInsulinThyroid HormonesGlutamineInsulinThyroid Hormonesandrogenestrogenglutaminehormoneinsulinprogesteroneprostaglandinthyroid hormone

Identifiers

PMID36077501
PMCPMC9456462
OpenAlexW4294733770

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.