Evidence map›Paper›PMID 36077548›Full record

ArticleInternational journal of molecular sciences2022

The Prostacyclin Analogue Iloprost Modulates CXCL10 in Systemic Sclerosis.

Tania Colasanti, Katia Stefanantoni, Cristina Fantini, Clarissa Corinaldesi, Massimiliano Vasile, Francesco Marampon, Luigi Di Luigi, Cristina Antinozzi, Paolo Sgrò, Andrea Lenzi and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. The Role of CXCL4 in Systemic Sclerosis: DAMP, Auto-Antigen and Biomarker.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Tania ColasantiRheumatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155-00161 Rome, Italy.ORCID 0000-0002-4413-1817
Katia StefanantoniRheumatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155-00161 Rome, Italy.ORCID 0000-0003-4209-8942
Cristina FantiniUnit of Biology and Genetics of Movement, Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Piazza Lauro de Bosis, 006-00135 Rome, Italy.
Clarissa CorinaldesiUnit of Endocrinology, Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Piazza Lauro de Bosis, 006-00135 Rome, Italy.
Massimiliano VasileRheumatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155-00161 Rome, Italy.
Francesco MaramponDepartment of Radiotherapy, Sapienza University of Rome, Viale del Policlinico, 155-00161 Rome, Italy.
Luigi Di LuigiUnit of Endocrinology, Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Piazza Lauro de Bosis, 006-00135 Rome, Italy.ORCID 0000-0002-2522-126X
Cristina AntinozziUnit of Endocrinology, Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Piazza Lauro de Bosis, 006-00135 Rome, Italy.ORCID 0000-0003-4296-5081
Paolo SgròUnit of Endocrinology, Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Piazza Lauro de Bosis, 006-00135 Rome, Italy.ORCID 0000-0003-4929-2764
Andrea LenziDepartment of Experimental Medicine, Sapienza University of Rome, Viale del Policlinico, 155-00161 Rome, Italy.
Valeria RiccieriRheumatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155-00161 Rome, Italy.
Clara CrescioliUnit of Endocrinology, Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Piazza Lauro de Bosis, 006-00135 Rome, Italy.ORCID 0000-0003-3339-3114
Foro Italico University of Rome · ITPoliclinico Umberto I · IT

Funding

Sapienza University of Rome 000031_19_rs_ Progetti Medi 2019Scientific Independence of young Researchers (SIR) Prot. n° RBSI14D5NX
6 · The paper itself

Abstract

The prostacyclin analogue iloprost is used to treat vascular alterations and digital ulcers, the early derangements manifesting in systemic sclerosis (SSc), an autoimmune disease leading to skin and organ fibrosis. Bioindicator(s) of SSc onset and progress are still lacking and the therapeutic approach remains a challenge. The T helper 1 (Th1) chemokine interferon (IFN)γ-induced protein 10 (IP-10/CXCL10) associates with disease progression and worse prognosis. Endothelial cells and fibroblasts, under Th1-dominance, release CXCL10, further enhancing SSc's detrimental status. We analyzed the effect of iloprost on CXCL10 in endothelial cells, dermal fibroblasts, and in the serum of SSc patients. Human endothelial cells and dermal fibroblasts activated with IFNγ/Tumor Necrosis Factor (TNF)α, with/without iloprost, were investigated for CXCL10 secretion/expression and for intracellular signaling cascade underlying chemokine release (Signal Transducer and Activator of Transcription 1, STAT1; Nuclear Factor kappa-light-chain-enhancer of activated B cells, NF-kB; c-Jun NH

Indexed as

IloprostScleroderma, SystemicChemokine CXCL10ChemokinesEndothelial CellsEpoprostenolHumansTumor Necrosis Factor-alphaChemokine CXCL10ChemokinesCXCL10 protein, humanEpoprostenolIloprostTumor Necrosis Factor-alphaCXCL10human endothelial cellshuman fibroblastsiloprostsystemic scleroderma

Identifiers

PMID36077548
PMCPMC9456348
OpenAlexW4294733701

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.