Evidence map›Paper›PMID 36077632›Full record

ArticleCancers2022

The Prognostic Value of Liquid Biopsies for Benefit of Salvage Radiotherapy in Relapsed Oligometastatic Prostate Cancer.

Natalia V Bogdanova, Hoda Radmanesh, Dhanya Ramachandran, Anne Caroline Knoechelmann, Hans Christiansen, Thorsten Derlin, Christoph Alexander Joachim von Klot, Roland Merten, Christoph Henkenberens

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Natalia V BogdanovaDepartment of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-9736-4593
Hoda RadmaneshDepartment of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany.
Dhanya RamachandranGynecology Research Unit, Clinics of Obstetrics and Gynaecology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0001-8139-7799
Anne Caroline KnoechelmannDepartment of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany.
Hans ChristiansenDepartment of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany.
Thorsten DerlinDepartment of Nuclear Medicine, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-8786-4105
Christoph Alexander Joachim von KlotClinic for Urology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-1877-7518
Roland MertenDepartment of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-2897-4064
Christoph HenkenberensDepartment of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany.
Medizinische Hochschule Hannover · DE

Funding

Dr.-Wolfgang-Dieckmann-Stiftung Molekulare Prädiktoren für die Strahlentherapie des PSMA-Liganden positiven Prostatakarzinomrezidivs - eine prospektive Beobachtungsstudie
6 · The paper itself

Abstract

To assess the prognostic value of "liquid biopsies" for the benefit of salvage RT in oligometastatic prostate cancer relapse, we enrolled 44 patients in the study between the years 2016 and 2020. All the patients were diagnosed as having an oligometastatic prostate cancer relapse on prostate-specific membrane antigen (PSMA)-targeted PET-CT and underwent irradiation at the Department of Radiotherapy at the Hannover Medical School. Tumor cells and total RNA, enriched from the liquid biopsies of patients, were processed for the subsequent quantification analysis of relative transcript levels in real-time PCR. In total, 54 gene transcripts known or suggested to be associated with prostate cancer or treatment outcome were prioritized for analysis. We found significant correlations between the relative transcript levels of several investigated genes and the Gleason score, PSA (prostate-specific antigen) value, or UICC stage (tumor node metastasis -TNM classification of malignant tumors from

Indexed as

circulating tumor cellsliquid biopsiesoligometastatic prostate cancerPSMA-PETsalvage radiotherapy

Identifiers

PMID36077632
PMCPMC9454496
OpenAlexW4293008570

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.