Evidence map›Paper›PMID 36077644›Full record

ArticleCancers2022

Real-World Data on Chronic Myelomonocytic Leukemia: Clinical and Molecular Characteristics, Treatment, Emerging Drugs, and Patient Outcomes.

Sandra Castaño-Díez, Mónica López-Guerra, Cristina Bosch-Castañeda, Alex Bataller, Paola Charry, Daniel Esteban, Francesca Guijarro, Carlos Jiménez-Vicente, Carlos Castillo-Girón, Albert Cortes and 9 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Research progress in diagnosis and treatment of pancreatic cancer with mismatch repair and microsatellite instability.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  3. IsolatedHaematologica · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Sandra Castaño-DíezHematology and Hematopathology Departments, Hospital Clínic Barcelona, 08036 Barcelona, Spain.ORCID 0000-0001-9044-4665
Mónica López-GuerraHematology and Hematopathology Departments, Hospital Clínic Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-5545-0178
Cristina Bosch-CastañedaMedical School, University of Barcelona, 08036 Barcelona, Spain.
Alex BatallerHematology and Hematopathology Departments, Hospital Clínic Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-6085-2745
Paola CharryHematology and Hematopathology Departments, Hospital Clínic Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-4777-9643
Daniel EstebanHematology and Hematopathology Departments, Hospital Clínic Barcelona, 08036 Barcelona, Spain.
Francesca GuijarroHematology and Hematopathology Departments, Hospital Clínic Barcelona, 08036 Barcelona, Spain.ORCID 0000-0001-6376-0929
Carlos Jiménez-VicenteHematology and Hematopathology Departments, Hospital Clínic Barcelona, 08036 Barcelona, Spain.
Carlos Castillo-GirónHematology and Hematopathology Departments, Hospital Clínic Barcelona, 08036 Barcelona, Spain.ORCID 0000-0003-3766-8621
Albert CortesHematology and Hematopathology Departments, Hospital Clínic Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-6260-901X
Alexandra Martínez-RocaHematology and Hematopathology Departments, Hospital Clínic Barcelona, 08036 Barcelona, Spain.ORCID 0000-0003-2143-5356
Ana TrigueroHematology and Hematopathology Departments, Hospital Clínic Barcelona, 08036 Barcelona, Spain.
José Ramón ÁlamoHematology and Hematopathology Departments, Hospital Clínic Barcelona, 08036 Barcelona, Spain.
Silvia BeàHematology and Hematopathology Departments, Hospital Clínic Barcelona, 08036 Barcelona, Spain.
Dolors CostaHematology and Hematopathology Departments, Hospital Clínic Barcelona, 08036 Barcelona, Spain.
Dolors ColomerHematology and Hematopathology Departments, Hospital Clínic Barcelona, 08036 Barcelona, Spain.ORCID 0000-0001-7486-8484
María RozmanHematology and Hematopathology Departments, Hospital Clínic Barcelona, 08036 Barcelona, Spain.
Jordi EsteveHematology and Hematopathology Departments, Hospital Clínic Barcelona, 08036 Barcelona, Spain.
Marina Díaz-BeyáHematology and Hematopathology Departments, Hospital Clínic Barcelona, 08036 Barcelona, Spain.
Hospital Clínic de Barcelona · ESJosep Carreras Leukaemia Research Institute · ESHospital de Sant Pau · ESUniversitat de Barcelona · ES

Funding

Hospital Clínic de Barcelona Contractes Clínic de Recerca Emili Letang-Josep Font 2021Instituto de Salud Carlos III FIS PI19/01476
6 · The paper itself

Abstract

Despite emerging molecular information on chronic myelomonocytic leukemia (CMML), patient outcome remains unsatisfactory and little is known about the transformation to acute myeloid leukemia (AML). In a single-center cohort of 219 CMML patients, we explored the potential correlation between clinical features, gene mutations, and treatment regimens with overall survival (OS) and clonal evolution into AML. The most commonly detected mutations were

Indexed as

AML transformationchronic myelomonocytic leukemiaclonal evolutionCMMLgene mutationshypomethylating agentsprognosissurvivaltargeted therapytreatment

Identifiers

PMID36077644
PMCPMC9455040
OpenAlexW4293104077

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.