Evidence map›Paper›PMID 36077899›Full record

ArticleAnimals : an open access journal from MDPI2022

Experimental Exposure to Bisphenol A Has Minimal Effects on Bone Tissue in Growing Rams-A Preliminary Study.

Jana Brankovič, Jakob Leskovec, Sabina Šturm, Vesna Cerkvenik-Flajs, Saša Šterpin, Joško Osredkar, Estera Pogorevc, David Antolinc, Milka Vrecl

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jana BrankovičInstitute of Preclinical Sciences, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1000 Ljubljana, Slovenia.ORCID 0000-0001-7934-3302
Jakob LeskovecDepartment of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, 1230 Domžale, Slovenia.
Sabina ŠturmInstitute of Pathology, Wild Animals, Fish and Bees, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1000 Ljubljana, Slovenia.
Vesna Cerkvenik-FlajsInstitute of Pathology, Wild Animals, Fish and Bees, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1000 Ljubljana, Slovenia.
Saša ŠterpinUniversity Institute of Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Zaloška Cesta 2, 1000 Ljubljana, Slovenia.
Joško OsredkarUniversity Institute of Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Zaloška Cesta 2, 1000 Ljubljana, Slovenia.ORCID 0000-0002-1839-2415
Estera PogorevcSmall Animal Clinic, Veterinary Faculty, University of Ljubljana, Cesta v Mestni log 47, 1000 Ljubljana, Slovenia.
David AntolincChair for Testing in Materials and Structures, Faculty of Civil and Geodetic Engineering, University of Ljubljana, Jamova 2, 1000 Ljubljana, Slovenia.ORCID 0000-0002-1142-076X
Milka VreclInstitute of Preclinical Sciences, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1000 Ljubljana, Slovenia.ORCID 0000-0002-9968-9228
University of Ljubljana · SILjubljana University Medical Centre · SI

Funding

Slovenian Research Agency P2-0185Slovenian Research Agency P4-0053Slovenian Research Agency P4-0092Slovenian Research Agency Postgraduate Research Funding
6 · The paper itself

Abstract

Bisphenol A (BPA) is a well-known synthetic compound that belongs to the group of endocrine-disrupting chemicals. Although bone tissue is a target for these compounds, studies on BPA-related effects on bone morphology in farm animals are limited. In this preliminary study, we investigated the effects of short-term dietary BPA exposure on femoral morphology, metabolism, mineral content, and biomechanical behavior in rams aged 9-12 months. Fourteen rams of the Istrian Pramenka breed were randomly divided into a BPA group and a control group (seven rams/group) and exposed to 25 µg BPA/kg bw for 64 days in feed. Blood was collected for determination of bone turnover markers (procollagen N-terminal propeptide, C-terminal telopeptide), and femurs were assessed via computed tomography, histomorphometry, three-point bending test, and mineral analysis. BPA had no significant effects on most of the parameters studied. Only mineral analysis showed decreased manganese (50%;

Indexed as

bisphenol Abone biomechanicsbone geometrycortical bonemineral contentramsserum bone biomarkerstrabecular bone

Identifiers

PMID36077899
PMCPMC9454980
OpenAlexW4293106141

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.