Evidence map›Paper›PMID 36078049›Full record

ReviewCells2022

Modelling Neurological Diseases in Large Animals: Criteria for Model Selection and Clinical Assessment.

Samantha L Eaton, Fraser Murdoch, Nina M Rzechorzek, Gerard Thompson, Claudia Hartley, Benjamin Thomas Blacklock, Chris Proudfoot, Simon G Lillico, Peter Tennant, Adrian Ritchie and 8 more

Abstract readReview
In one paragraph

Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Samantha L EatonRoyal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian EH25 9RG, UK.
Fraser MurdochRoyal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian EH25 9RG, UK.
Nina M RzechorzekMedical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.ORCID 0000-0003-3209-5019
Gerard ThompsonCentre for Clinical Brain Sciences, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
Claudia HartleyRoyal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian EH25 9RG, UK.ORCID 0000-0002-1246-6479
Benjamin Thomas BlacklockRoyal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian EH25 9RG, UK.ORCID 0000-0003-4136-5674
Chris ProudfootThe Large Animal Research & Imaging Facility, Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian EH25 9RG, UK.ORCID 0000-0002-3903-9901
Simon G LillicoRoyal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian EH25 9RG, UK.
Peter TennantThe Large Animal Research & Imaging Facility, Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian EH25 9RG, UK.
Adrian RitchieThe Large Animal Research & Imaging Facility, Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian EH25 9RG, UK.
James NixonThe Large Animal Research & Imaging Facility, Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian EH25 9RG, UK.
Paul M BrennanTranslational Neurosurgery, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.ORCID 0000-0002-7347-830X
Stefano GuidoRoyal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian EH25 9RG, UK.
Nadia L MitchellFaculty of Agriculture and Life Sciences, Lincoln University, P.O. Box 85084, Lincoln 7647, New Zealand.ORCID 0000-0003-4801-2804
David N PalmerFaculty of Agriculture and Life Sciences, Lincoln University, P.O. Box 85084, Lincoln 7647, New Zealand.
C Bruce A WhitelawRoyal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian EH25 9RG, UK.ORCID 0000-0002-2918-1605
Jonathan D CooperDepartments of Pediatrics, Genetics, and Neurology, Washington University School of Medicine in St. Louis, 660 S Euclid Ave, St. Louis, MO 63110, USA.ORCID 0000-0003-1339-4750
Thomas M WishartRoyal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian EH25 9RG, UK.

Funding

Characterizing and testing the efficacy of AAV-mediated gene therapy in a sheep model of CLN1 disease.R01NS124655 · NINDS · WASHINGTON UNIVERSITY · PI COOPER, JONATHAN D · 2022 to 2025
$1.9M
Characterizing and testing the efficacy of AAV-mediated gene therapy in a novel CRISPR/Cas9 generated sheep model of Cln1 disease.R56NS117635 · NINDS · WASHINGTON UNIVERSITY · PI COOPER, JONATHAN D · 2021 to 2021
$502k
Biotechnology and Biological Sciences Research Council BB/J004316/1Biotechnology and Biological Sciences Research Council BB/P013732/1Medical Research Council MC_EX_MR/S022023/1Medical Research Council MR/S022023/1NINDS NIH HHS R01 NS124655NINDS NIH HHS R56 NS117635
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Nervous System DiseasesAnimalsDisease ProgressionHumansMammalsModels, Animalclinical assessmentlarge animal modelmodel selection criterianeurological disease

Identifiers

PMID36078049
PMCPMC9454934

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.