Evidence map›Paper›PMID 36078142›Full record

ArticleCells2022

Apigetrin Promotes TNFα-Induced Apoptosis, Necroptosis, G2/M Phase Cell Cycle Arrest, and ROS Generation through Inhibition of NF-κB Pathway in Hep3B Liver Cancer Cells.

Pritam Bhagwan Bhosale, Abuyaseer Abusaliya, Hun Hwan Kim, Sang Eun Ha, Min Yeong Park, Se Hyo Jeong, Preethi Vetrivel, Jeong Doo Heo, Jin-A Kim, Chung Kil Won and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Apigenin 7-glucoside reprograms tumor metabolism and enhances immunotherapy efficacy in colorectal cancer via DLX5.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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  7. Review
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  9. The Role of Dandelion (Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  10. Review
  11. Article
  12. Article
  13. London Rocket (Molecules (Basel, Switzerland) · 2024
    Article
  14. Biomolecules & biomedicine · 2024
    Article
  15. Profiles of phenolics and their synthetic pathways inFood chemistry. Molecular sciences · 2024
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Pritam Bhagwan BhosaleDepartment of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, Jinju 52828, Korea.ORCID 0000-0003-1691-7844
Abuyaseer AbusaliyaDepartment of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, Jinju 52828, Korea.ORCID 0000-0001-6088-1485
Hun Hwan KimDepartment of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, Jinju 52828, Korea.
Sang Eun HaDepartment of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, Jinju 52828, Korea.
Min Yeong ParkDepartment of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, Jinju 52828, Korea.
Se Hyo JeongDepartment of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, Jinju 52828, Korea.
Preethi VetrivelDepartment of Pharmacy, National University of Singapore, Singapore 117643, Singapore.
Jeong Doo HeoDepartment of Pharmacy, National University of Singapore, Singapore 117643, Singapore.
Jin-A KimDepartment of Physical Therapy, International University of Korea, Jinju 52833, Korea.
Chung Kil WonDepartment of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, Jinju 52828, Korea.
Hyun-Wook KimDivision of Animal Bioscience & Intergrated Biotechnology, Jinju 52725, Korea.
Gon Sup KimDepartment of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University, Jinju 52828, Korea.ORCID 0000-0001-7048-458X
Gyeongsang National University · KRNational University of Singapore · SGInternational University of Korea · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apigetrin (7-(β-D-glucopyranosyloxy)-4',5-dihydroxyflavone), a glycoside bioactive dietary flavonoid derived from

Indexed as

ApigeninCarcinoma, HepatocellularLiver NeoplasmsApoptosisCell Line, TumorHumansM Phase Cell Cycle CheckpointsNecroptosisNF-kappa BReactive Oxygen SpeciesTumor Necrosis Factor-alphaApigeninapigetrinNF-kappa BReactive Oxygen SpeciesTumor Necrosis Factor-alphaapigetrinapoptosisflavonoidsliver cancernecroptosisreactive oxygen species

Identifiers

PMID36078142
PMCPMC9454891
OpenAlexW4294152606

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.