ArticleInternational journal of environmental research and public health2022
Excellent Response to OnabotulinumtoxinA: Different Definitions, Different Predictors.
Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Review
- Risk factors affecting the therapeutic effect of onabotulinum toxin a on chronic migraine.Pain management · 2025Article
- [Gender-specific results of the Dresden children and adolescents headache program DreKiP].Schmerz (Berlin, Germany) · 2024Article
- Article
- Searching for the Predictors of Response to BoNT-A in Migraine Using Machine Learning Approaches.Toxins · 2023Article
- Real Life Data on OnabotulinumtoxinA for Treatment of Chronic Migraine in Pediatric Age.Journal of clinical medicine · 2023Article
- Review
- Real-world experience of OnabotulinumtoxinA treatment in female patients with chronic migraine: a qualitative study using in-depth interviews.Annals of medicine · 2023Article
- Article
- Article
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Authors and funding
32 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identification of patients who can benefit the most from the available preventive treatments is important in chronic migraine. We explored the rate of excellent responders to onabotulinumtoxinA in a multicenter European study and explored the predictors of such response, according to different definitions. A pooled analysis on chronic migraineurs treated with onabotulinumtoxinA and followed-up for, at least, 9 months was performed. Excellent responders were defined either as patients with a ≥75% decrease in monthly headache days (percent-based excellent responders) or as patients with <4 monthly headache days (frequency-based excellent responders). The characteristics of excellent responders at the baseline were compared with the ones of patients with a <30% decrease in monthly headache days. Percent-based excellent responders represented about 10% of the sample, whilst frequency-based excellent responders were about 5% of the sample. Compared with non-responders, percent-based excellent responders had a higher prevalence of medication overuse and a higher excellent response rate even after the 1st and the 2nd injection. Females were less like to be frequency-based excellent responders. Chronic migraine sufferers without medication overuse and of female sex may find fewer benefits with onabotulinumtoxinA. Additionally, the excellent response status is identifiable after the first cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.