Evidence map›Paper›PMID 36080517›Full record

ReviewPolymers2022

Small Diameter Cell-Free Tissue-Engineered Vascular Grafts: Biomaterials and Manufacture Techniques to Reach Suitable Mechanical Properties.

María A Rodríguez-Soto, Camilo A Polanía-Sandoval, Andrés M Aragón-Rivera, Daniel Buitrago, María Ayala-Velásquez, Alejandro Velandia-Sánchez, Gabriela Peralta Peluffo, Juan C Cruz, Carolina Muñoz Camargo, Jaime Camacho-Mackenzie and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. [Research progress on calcification mechanism and anti-calcification strategies of vascular grafts].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. The extracellular matrix mechanics in the vasculature.Nature cardiovascular research · 2023
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

María A Rodríguez-SotoDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, Colombia.ORCID 0000-0002-9979-2815
Camilo A Polanía-SandovalVascular and Endovascular Surgery Research Group, Fundación Cardio Infantil-Instituto de Cardiología, Bogotá 111711, Colombia.
Andrés M Aragón-RiveraDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, Colombia.
Daniel BuitragoDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, Colombia.
María Ayala-VelásquezDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, Colombia.
Alejandro Velandia-SánchezVascular and Endovascular Surgery Research Group, Fundación Cardio Infantil-Instituto de Cardiología, Bogotá 111711, Colombia.ORCID 0000-0001-6681-1883
Gabriela Peralta PeluffoDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, Colombia.
Juan C CruzDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, Colombia.ORCID 0000-0002-7790-7546
Carolina Muñoz CamargoDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, Colombia.ORCID 0000-0001-6238-9021
Jaime Camacho-MackenzieVascular and Endovascular Surgery Research Group, Fundación Cardio Infantil-Instituto de Cardiología, Bogotá 111711, Colombia.
Juan Guillermo Barrera-CarvajalVascular and Endovascular Surgery Research Group, Fundación Cardio Infantil-Instituto de Cardiología, Bogotá 111711, Colombia.
Juan Carlos BriceñoDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, Colombia.
Universidad de Los Andes · COInstitute of Cardiology · CO

Funding

Minciencias 1544101252100, 635-2021
6 · The paper itself

Abstract

Vascular grafts (VGs) are medical devices intended to replace the function of a blood vessel. Available VGs in the market present low patency rates for small diameter applications setting the VG failure. This event arises from the inadequate response of the cells interacting with the biomaterial in the context of operative conditions generating chronic inflammation and a lack of regenerative signals where stenosis or aneurysms can occur. Tissue Engineered Vascular grafts (TEVGs) aim to induce the regeneration of the native vessel to overcome these limitations. Besides the biochemical stimuli, the biomaterial and the particular micro and macrostructure of the graft will determine the specific behavior under pulsatile pressure. The TEVG must support blood flow withstanding the exerted pressure, allowing the proper compliance required for the biomechanical stimulation needed for regeneration. Although the international standards outline the specific requirements to evaluate vascular grafts, the challenge remains in choosing the proper biomaterial and manufacturing TEVGs with good quality features to perform satisfactorily. In this review, we aim to recognize the best strategies to reach suitable mechanical properties in cell-free TEVGs according to the reported success of different approaches in clinical trials and pre-clinical trials.

Indexed as

biodegradablebiomaterialsbiomechanical stimulationmechanical propertiestissue engineered vascular grafts

Identifiers

PMID36080517
PMCPMC9460130
OpenAlexW4292879428

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.