Evidence mapPaperPMID 36081339Full record

ArticleDrug delivery2022

Pitavastatin-loaded bilosomes for oral treatment of hepatocellular carcinoma: a repurposing approach.

Maged Kharouba, Amal El-Kamel, Radwa Mehanna, Eman Thabet, Lamia Heikal

Open access · goldAbstract read
In one paragraph

Article in Drug delivery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Maged KharoubaDepartment of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Amal El-KamelDepartment of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Radwa MehannaMedical Physiology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Eman ThabetMedical Physiology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Lamia HeikalDepartment of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Alexandria University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Albeit its established efficacy as an anti-hyperlipidemic agent, pitavastatin (PIT) has been shown to have other various therapeutic effects. One of these effects is the anti-cancer activity against hepatocellular carcinoma (HCC). This effect has been evaluated in this study for the first time

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsBile Acids and SaltsCaco-2 CellsHumansLiposomesParticle SizePhospholipidsQuinolinesBile Acids and SaltsLiposomesPhospholipidspitavastatinQuinolines3D spheroidanti-cancerCaco-2HepG2liver carcinomapitavastatinRepurposing

Identifiers

PMID36081339
PMCPMC9467608
OpenAlexW4295086782

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.