Evidence map›Paper›PMID 36083108›Full record

ArticleThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry2023

The decoupling of structural and functional connectivity of auditory networks in individuals at clinical high-risk for psychosis.

Mina Langhein, Amanda E Lyall, Saskia Steinmann, Johanna Seitz-Holland, Felix L Nägele, Suheyla Cetin-Karayumak, Fan Zhang, Jonas Rauh, Marius Mußmann, Tashrif Billah and 8 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 2 countries.

Mina LangheinPsychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Amanda E LyallPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Saskia SteinmannPsychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Johanna Seitz-HollandPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Felix L NägelePsychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0003-3774-6765
Suheyla Cetin-KarayumakPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Fan ZhangDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jonas RauhPsychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Marius MußmannPsychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Tashrif BillahPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nikos MakrisPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ofer PasternakPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Lauren J O'DonnellDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Yogesh RathiPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Gregor LeichtPsychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-5104-9336
Marek KubickiPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Martha E ShentonPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Christoph MulertPsychiatry Neuroimaging Branch, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Brigham and Women's Hospital · USUniversität Hamburg · DE

Funding

Training and DisseminationP41EB015902 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, RON, WESTIN, CARL-FREDRIK · 2012 to 2022
$20.9M
Image Guided Therapy Center - Ultrasound-based sensor system for the monitoring of COVID-19 patientsP41EB015898 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI TEMPANY, CLARE M · 2012 to 2021
$18.9M
TRD 3 - Enabling Technologies for Intraprocedural GuidanceP41EB028741 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI Oliver Jonas · 2021 to 2026
$10.7M
Novel DT-MRI Analyses of White Matter in SchizophreniaR01MH074794 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI WESTIN, CARL-FREDRIK · 2007 to 2021
$9.6M
Human Connectome Project for Early PsychosisU01MH109977 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI BREIER, ALAN, SHENTON, MARTHA E. · 2016 to 2020
$5.5M
Harmonizing multi-site diffusion MRI acquisitions for neuroscientific analysis across ages and brain disordersR01MH119222 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI O'DONNELL, LAUREN JEAN, RATHI, YOGESH · 2019 to 2023
$4.0M
Quantitative Glioblastoma Margin and Infiltration Mapping with Advanced Diffusion-Relaxation MRIR01NS125781 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI ALEXANDRA J GOLBY, Carl-Fredrik Westin · 2022 to 2026
$3.6M
Diffusion Imaging Biomarkers for Risk, Onset and Outcome in SchizophreniaR01MH102377 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK · 2014 to 2018
$2.8M
Next Generation Diffusion MRI Biomarkers for Prodromal SchizophreniaR01MH108574 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI PASTERNAK, OFER · 2016 to 2020
$2.2M
Open source diffusion MRI technology for brain cancer researchU01CA199459 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI O'DONNELL, LAUREN JEAN · 2015 to 2017
$1.1M
Mentoring and Neuroimaging Research on White Matter Pathology in SchizophreniaK24MH110807 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK · 2017 to 2021
$945k
Neuroimaging of the Biological Correlates of Early Psychosis: A MR-PET StudyK01MH115247 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI LYALL, AMANDA ELLIS · 2018 to 2022
$889k
NCI NIH HHS U01 CA199459NIBIB NIH HHS P41 EB015898NIBIB NIH HHS P41 EB015902NIBIB NIH HHS P41 EB028741NIMH NIH HHS K01 MH115247NIMH NIH HHS K24 MH110807NIMH NIH HHS R01 MH074794NIMH NIH HHS R01 MH102377NIMH NIH HHS R01 MH108574NIMH NIH HHS R01 MH119222NIMH NIH HHS R03 MH110745NIMH NIH HHS U01 MH109977NINDS NIH HHS R01 NS125781
6 · The paper itself

Abstract

objectivesDisrupted auditory networks play an important role in the pathophysiology of psychosis, with abnormalities already observed in individuals at clinical high-risk for psychosis (CHR). Here, we examine structural and functional connectivity of an auditory network in CHR utilising state-of-the-art electroencephalography and diffusion imaging techniques.

methodsTwenty-six CHR subjects and 13 healthy controls (HC) underwent diffusion MRI and electroencephalography while performing an auditory task. We investigated structural connectivity, measured as fractional anisotropy in the Arcuate Fasciculus (AF), Cingulum Bundle, and Superior Longitudinal Fasciculus-II. Gamma-band lagged-phase synchronisation, a functional connectivity measure, was calculated between cortical regions connected by these tracts.

resultsCHR subjects showed significantly higher structural connectivity in the right AF than HC (

conclusionsWe observe significant differences in structural connectivity of the AF, without a concomitant significant change in functional connectivity in CHR subjects. This may suggest that the CHR state is characterised by a decoupling of structural and functional connectivity, possibly due to abnormal white matter maturation.

Indexed as

Psychotic DisordersSchizophreniaWhite MatterElectroencephalographyHumansMagnetic Resonance Imagingbiological psychiatryEEGimagingMRIschizophrenia

Identifiers

PMID36083108
PMCPMC10399965
OpenAlexW4295037931

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.