Evidence map›Paper›PMID 36088317›Full record

ArticleBMC medical genomics2022

Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations.

Mohammad Yaser Anwar, Antoine R Baldassari, Hannah G Polikowsky, Colleen M Sitlani, Heather M Highland, Nathalie Chami, Hung-Hsin Chen, Mariaelisa Graff, Annie Green Howard, Su Yon Jung and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 11 institutions in 1 country.

Mohammad Yaser AnwarDepartment of Epidemiology, University of North Carolina at Chapel Hill, 123 West Franklin Street, CVD Genetic Epidemiology Lab, Fl #4, Room A7, Chapel Hill, NC, 27599, USA. myaser@unc.edu.
Antoine R BaldassariDepartment of Epidemiology, University of North Carolina at Chapel Hill, 123 West Franklin Street, CVD Genetic Epidemiology Lab, Fl #4, Room A7, Chapel Hill, NC, 27599, USA.
Hannah G PolikowskyVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Colleen M SitlaniDepartment of Medicine, University of Washington, Seattle, WA, 98195, USA.
Heather M HighlandDepartment of Epidemiology, University of North Carolina at Chapel Hill, 123 West Franklin Street, CVD Genetic Epidemiology Lab, Fl #4, Room A7, Chapel Hill, NC, 27599, USA.
Nathalie ChamiThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hung-Hsin ChenVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Mariaelisa GraffDepartment of Epidemiology, University of North Carolina at Chapel Hill, 123 West Franklin Street, CVD Genetic Epidemiology Lab, Fl #4, Room A7, Chapel Hill, NC, 27599, USA.
Annie Green HowardDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Su Yon JungTranslational Sciences Section, School of Nursing, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Lauren E PettyVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Zhe WangThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Wanying ZhuVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Steven BuyskeDepartment of Statistics, Rutgers University, Piscataway, NJ, 08854, USA.
Iona ChengDepartment of Epidemiology and Biostatistics, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, 94115, USA.
Robert KaplanAlbert Einstein College of Medicine, Bronx, NY, 10461, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ulrike PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Joseph B McCormickSchool of Public Health, University of Texas Health Science Center at Houston, Brownsville Regional Campus, Brownsville, TX, 78520, USA.
Susan P Fisher-HochSchool of Public Health, University of Texas Health Science Center at Houston, Brownsville Regional Campus, Brownsville, TX, 78520, USA.
Christy L AveryDepartment of Epidemiology, University of North Carolina at Chapel Hill, 123 West Franklin Street, CVD Genetic Epidemiology Lab, Fl #4, Room A7, Chapel Hill, NC, 27599, USA.
Kira C TaylorDepartment of Epidemiology and Population Health, University of Louisville School of Public Health and Information Sciences, Louisville, KT, 40202, USA.
Jennifer E BelowVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, 123 West Franklin Street, CVD Genetic Epidemiology Lab, Fl #4, Room A7, Chapel Hill, NC, 27599, USA.
University of North Carolina at Chapel Hill · USVanderbilt University Medical Center · USIcahn School of Medicine at Mount Sinai · USFred Hutch Cancer Center · USThe University of Texas Health Science Center at Houston · USAlbert Einstein College of Medicine · USRutgers, The State University of New Jersey · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Louisville · USUniversity of Washington · US

Funding

VALIDATION OF A DIET HISTORY METHOD FOR EPIDEMIOLOGIC STUDIES OF CANCERP01CA033619 · UNIVERSITY OF HAWAII AT MANOA · 1985 to 2004
$14.1M
THE PURPOSE OF THIS MODIFICATION IS TO DE-OBLIGATE NHLBI FUNDING FROM THE WOMEN'S HEALTH INITIATIVE (WHI) - CLINICAL COORDINATING CENTER (CCC).75N92021D00001 · FRED HUTCHINSON CANCER CENTER · 2025 to 2025
$9.3M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · UNIV OF NORTH CAROLINA CHAPEL HILL · 2001 to 2025
$6.9M
Breast &Prostate Cancer &Hormone-related Gene VariantsU01CA098758 · UNIVERSITY OF SOUTHERN CALIFORNIA · 2003 to 2005
$6.5M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · UNIVERSITY OF HAWAII AT MANOA · 2003 to 2005
$6.4M
Obesity and Type II Diabetes PilotP20MD000170 · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2003 to 2005
$3.8M
NYR-Diabetes Research Center (NYR-DRC)P30DK020541 · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2025 to 2025
$2.4M
Thalassemia Clinical Research Network, CanadaU01HL065233 · UNIVERSITY HEALTH NETWORK · 2000 to 2005
$1.9M
Inflammatory mediators of cardiometabolic risk in LatinosR01HL147853 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Christy Leigh Avery · 2022 to 2023
$1.8M
GENETIC ARCHITECTURE OF PLASMA T-PA AND PAI-1R01HL065234 · VANDERBILT UNIVERSITY · 2000 to 2004
$1.7M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC): TASK AREA A AND A275N92021D00002 · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2025 to 2025
$1.2M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC): TASK AREA A AND A275N92021D00004 · STANFORD UNIVERSITY · 2025 to 2025
$1.1M
NCATS NIH HHS UL1 TR000371NCI NIH HHS HHSN261201300004INCI NIH HHS HHSN261201300005INCI NIH HHS P01 CA033619NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA098758NCI NIH HHS U01 CA136792NHGRI NIH HHS R01 HG010297NHGRI NIH HHS R56 HG010297NHGRI NIH HHS U01 HG004802NHLBI NIH HHS 75N92021D00001NHLBI NIH HHS 75N92021D00002NHLBI NIH HHS HHSN268201000001INHLBI NIH HHS HHSN268201000021CNHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201200008INHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS N01HC65233NHLBI NIH HHS N01HC65234NHLBI NIH HHS N01HC65235NHLBI NIH HHS N01HC65236NHLBI NIH HHS N01HC65237NHLBI NIH HHS R01 HL142825NHLBI NIH HHS R01 HL143885NHLBI NIH HHS R01 HL147853NHLBI NIH HHS T32 HL129982NIDDK NIH HHS P30 DK020541NIDDK NIH HHS R01 DK122503NIEHS NIH HHS P30 ES010126NIMHD NIH HHS P20 MD000170WHI NIH HHS 75N92021D00003WHI NIH HHS 75N92021D00004WHI NIH HHS 75N92021D00005
6 · The paper itself

Abstract

backgroundConcurrent variation in adiposity and inflammation suggests potential shared functional pathways and pleiotropic disease underpinning. Yet, exploration of pleiotropy in the context of adiposity-inflammation has been scarce, and none has included self-identified Hispanic/Latino populations. Given the high level of ancestral diversity in Hispanic American population, genetic studies may reveal variants that are infrequent/monomorphic in more homogeneous populations.

methodsUsing multi-trait Adaptive Sum of Powered Score (aSPU) method, we examined individual and shared genetic effects underlying inflammatory (CRP) and adiposity-related traits (Body Mass Index [BMI]), and central adiposity (Waist to Hip Ratio [WHR]) in HLA participating in the Population Architecture Using Genomics and Epidemiology (PAGE) cohort (N = 35,871) with replication of effects in the Cameron County Hispanic Cohort (CCHC) which consists of Mexican American individuals.

resultsOf the > 16 million SNPs tested, variants representing 7 independent loci were found to illustrate significant association with multiple traits. Two out of 7 variants were replicated at statistically significant level in multi-trait analyses in CCHC. The lead variant on APOE (rs439401) and rs11208712 were found to harbor multi-trait associations with adiposity and inflammation.

conclusionsResults from this study demonstrate the importance of considering pleiotropy for improving our understanding of the etiology of the various metabolic pathways that regulate cardiovascular disease development.

Indexed as

AdiposityGenetic PleiotropyHispanic or LatinoHumansInflammationObesityGenetic pleiotropyHispanic AmericansInflammationObesity

Identifiers

PMID36088317
PMCPMC9464371
OpenAlexW4295491958

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.