ArticleBritish journal of cancer2022
Maternal diabetes and childhood cancer risks in offspring: two population-based studies.
Article in British journal of cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Parental and childhood exposures and the risk of retinoblastoma, hepatoblastoma, and germ cell, bone, and soft tissue tumors in children: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Maternal Alcohol Consumption and Risk of Childhood Cancers: A Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2025Pooled it
- Risk factors of neuroblastoma: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Risk factors for childhood brain tumours: A systematic review and meta-analysis of observational studies from 1976 to 2022.Cancer epidemiology · 2024Pooled it
- A Population-Based Assessment of Cancer Risk in Children With VACTERL.American journal of medical genetics. Part A · 2026Article
- Exposure to nitrosatable drugs during pregnancy and childhood cancer: A cohort study in Taiwan.International journal of cancer · 2026Article
- Application of an obstetric comorbidity index to predict childhood cancer risk: a population based case-control study in Denmark.British journal of cancer · 2025Article
- Global, regional, and national burden of hepatoblastoma, 1990-2021: a systematic analysis of the global burden of disease study 2021.International journal of surgery (London, England) · 2025Article
- Maternal autoimmune disease and its association with childhood cancer: A population-based case-control study in Denmark.EJC paediatric oncology · 2024Article
- Maternal medically diagnosed infection and antibiotic prescription during pregnancy and risk of childhood cancer: A population-based cohort study in Taiwan, 2004 to 2015.International journal of cancer · 2024Article
- The Relationship Between Gestational Diabetes and the Risk of Cancer: A Systematic Review.Cureus · 2024Review
- Racial and ethnic and socioeconomic disparities in childhood cancer incidence trends in the United States, 2000-2019.Journal of the National Cancer Institute · 2023Article
- The neonatal blood spot metabolome in retinoblastoma.EJC paediatric oncology · 2023Article
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Authors and funding
10 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundThe effect of maternal diabetes on childhood cancer has not been widely studied.
methodsWe examined this in two population-based studies in Denmark (N = 6420 cancer cases, 160,484 controls) and Taiwan (N = 2160 cancer cases, 2,076,877 non-cases) using logistic regression and Cox proportional hazard regression adjusted for birth year, child's sex, maternal age and birth order.
resultsGestational diabetes in Denmark [odds ratio (OR) = 0.98, 95% confidence interval (CI): 0.71-1.35] or type II and gestational diabetes in Taiwan (type II: hazard ratio (HR) = 0.81, 95% CI: 0.63-1.05; gestational diabetes: HR = 1.06, 95% CI: 0.92-1.22) were not associated with cancer (all types combined). In Denmark, maternal type I diabetes was associated with the risk of glioma (OR = 2.33, 95% CI: 1.04-5.22), while in Taiwan, the risks of glioma (HR = 1.59, 95% CI: 1.01-2.50) were elevated among children whose mothers had gestational diabetes. There was a twofold increased risk for hepatoblastoma with maternal type II diabetes (HR = 2.02, 95% CI: 1.02-4.00).
conclusionsOur results suggest that maternal diabetes is an important risk factor for certain types of childhood cancers, emphasising the need for effective interventions targeting maternal diabetes to prevent serious health effects in offspring.
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