Evidence map›Paper›PMID 36089546›Full record

ArticleChemMedChem2022

From DC18 to MR07: A Metabolically Stable 4,4'-Oxybisbenzoyl Amide as a Low-Nanomolar Growth Inhibitor of P. falciparum.

Ivan Bassanini, Silvia Parapini, Nicoletta Basilico, Donatella Taramelli, Sergio Romeo

Abstract read
In one paragraph

Article in ChemMedChem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Proposition ofCombinatorial chemistry & high throughput screening · 2024
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ivan BassaniniIstituto di Scienze e Tecnologie Chimiche "Giulio Natta", Consiglio Nazionale delle Ricerche, Via Mario Bianco 9, 20131, Milano, Italy.ORCID 0000-0001-9589-3689
Silvia ParapiniDipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Via Pascal 36, 20133, Milano, Italy.ORCID 0000-0003-2079-8892
Nicoletta BasilicoDipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, Via Pascal 36, 20133, Milano, Italy.ORCID 0000-0001-9030-1066
Donatella TaramelliDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Pascal 36, 20133, Milano, Italy.ORCID 0000-0001-5108-4492
Sergio RomeoDipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, 20133, Milano, Italy.ORCID 0000-0003-4692-7314

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To improve the metabolic stability of a 4,4'-oxybisbenzoyl-based novel and potent (nanomolar-range IC

Indexed as

AntimalarialsMalaria, FalciparumAmidesGrowth InhibitorsHumansPlasmodium falciparumStructure-Activity RelationshipAmidesAntimalarialsGrowth InhibitorsAntimalarialsIn silico pharmacophore mappingIn vitro metabolic stabilityMalariaPlasmodium falciparum

Identifiers

PMID36089546
PMCPMC9827966

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.