Evidence map›Paper›PMID 36090148›Full record

ArticleCurrent otorhinolaryngology reports2020

Advances in Inner Ear Therapeutics for Hearing Loss in Children.

Ksenia A Aaron, Grace S Kim, Alan G Cheng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current otorhinolaryngology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ksenia A AaronDepartment of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, CA, 94305, USA.
Grace S KimDepartment of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, CA, 94305, USA.
Alan G ChengDepartment of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, CA, 94305, USA.
Palo Alto University · US

Funding

Mouse vestibular regeneration and functionR01DC016919 · NIDCD · STANFORD UNIVERSITY · PI Alan Gi-Lun Cheng · 2019 to 2026
$4.9M
Pathways towards regenerating the mammalian cochleaR01DC013910 · NIDCD · STANFORD UNIVERSITY · PI CHENG, ALAN GI-LUN · 2015 to 2019
$2.1M
Clinician-scientist training program in otolaryngologyT32DC015209 · NIDCD · STANFORD UNIVERSITY · PI CHENG, ALAN GI-LUN · 2016 to 2021
$807k
NIDCD NIH HHS R01 DC013910NIDCD NIH HHS R01 DC016919NIDCD NIH HHS T32 DC015209
6 · The paper itself

Abstract

Purpose of review: Hearing loss is a common congenital sensory disorder with various underlying causes. Here, we review and focus on genetic, infectious, and ototoxic causes and recent advances in inner ear therapeutics. Recent findings: While hearing aids and cochlear implantation are the mainstay of treatment for pediatric hearing loss, novel biological therapeutics are being explored. Recent preclinical studies report positive results in viral-mediated gene transfer techniques and surgical approaches to the inner ear for genetic hearing loss. Novel pharmacologic agents, on the other hand, show promising results in reducing aminoglycoside and cisplatin ototoxicity. Clinical trials are underway to evaluate the efficacy of antivirals for cytomegalovirus-related hearing loss, and its pathogenesis and other potential therapeutics are currently under investigation. Summary: Individualized therapies for genetic and infectious causes of sensorineural hearing loss in animal models as well as pediatric patients show promising results, with their potential efficacy being active areas of research.

Indexed as

CMVCongenitalGene therapyHearing lossPediatric

Identifiers

PMID36090148
PMCPMC9455742
OpenAlexW3038191904

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.