ArticleFrontiers in neurology2022
Associations of sleep apnea risk and oxygen desaturation indices with cerebral small vessel disease burden in patients with stroke.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 11 citations in OpenAlex.
- [Construction of OSA-related hypertension prediction model based on nomogram].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Article
- Correlation between obstructive sleep apnea and hypoperfusion in patients with acute cerebral infarction.Frontiers in neurology · 2024Article
- Prevalence, incidence, and the time trends of sleep-disordered breathing among patients with stroke: a systematic review and meta-analysis.Frontiers in neurology · 2024Review
- Correlation between obstructive sleep apnea and cerebral small vessel disease: a mendelian randomization study.Genes & genomics · 2023Article
- Prediction model of obstructive sleep apnea-related hypertension: Machine learning-based development and interpretation study.Frontiers in cardiovascular medicine · 2022Article
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5 authors at 1 institution in 1 country.
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Abstract
Background: Obstructive sleep apnea (OSA) is associated with cerebral small vessel disease (CSVD). Nonetheless, whether OSA-risk determined by a simple screening questionnaire or indices quantifying nocturnal hypoxemia other than the conventional apnea-hypopnea index (AHI) by the home sleep apnea test (HSAT) associated with CSVD burden remains uncertain. Methods: From 2018 to 2021, we recruited patients with transient ischemic attack (TIA)/minor stroke from the Queen Mary Hospital Acute Stroke Unit and TIA/Stroke Outpatient Clinics. Logistic regression models were applied to determine the association of baseline OSA-risk (on STOP-BANG questionnaire) or HSAT-derived indices quantifying nocturnal hypoxemia with global burden/individual markers of CSVD on MRI. Indices included oxygen desaturation (≥3%) index (ODI), minimum oxygen saturation (SpO Results: In 283 patients with TIA/minor stroke (mean age 65 years, 64% men), OSA-risk was significantly associated with total CSVD score (multivariate-adjusted odds ratio: 1.23, 95% confidence interval 1.01-1.51), presence of lacunes [1.39 (1.09-1.79)] and burden of basal ganglia PVSs [1.32 (1.06-1.67)]. In 85/283 patients who completed HSAT, neither AHI, minimum SpO Conclusion: In patients with TIA/minor stroke, high OSA-risk was associated with a greater CSVD burden. Oxygen desaturation indices (ODI and DesDur) rather than AHI were independently associated with global CSVD burden, indicating that longer and more severe desaturations may contribute to the pathogenesis of CSVD.
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