Evidence map›Paper›PMID 36091043›Full record

ArticleFrontiers in immunology2022

PD-1

Haixia Wei, Anqi Xie, Jiajie Li, Chao Fang, Lin Liu, Junmin Xing, Feihu Shi, Feng Mo, Dianhui Chen, Hongyan Xie and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. T cell exhaustion in parasitic infections.Frontiers in immunology · 2026
    Review
  3. Review
  4. Article
  5. Stress induces corticosterone-mediated CD8Cancer immunology, immunotherapy : CII · 2025
    Article
  6. Review
  7. Review
  8. Characteristics of splenic PD-1Immunologic research · 2024
    Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Haixia WeiDepartment of Infectious Diseases, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Anqi XieDepartment of Basic Medical Science, China Sino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou, China.
Jiajie LiDepartment of Basic Medical Science, China Sino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou, China.
Chao FangDepartment of Basic Medical Science, China Sino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou, China.
Lin LiuDepartment of Basic Medical Science, China Sino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou, China.
Junmin XingDepartment of Basic Medical Science, China Sino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou, China.
Feihu ShiDepartment of Infectious Diseases, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Feng MoDepartment of Infectious Diseases, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Dianhui ChenDepartment of Infectious Diseases, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Hongyan XieDepartment of Basic Medical Science, China Sino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou, China.
Quan YangDepartment of Basic Medical Science, China Sino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou, China.
Xingfei PanDepartment of Infectious Diseases, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiaoping TangGuangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
Jun HuangDepartment of Basic Medical Science, China Sino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou, China.
Guangzhou Medical University · CNThird Affiliated Hospital of Guangzhou Medical University · CNGuangzhou Eighth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The morbidity and mortality of malaria are still high. Programmed cell death-1(PD-1) is an important co-inhibitory factor and CD8 T cells with PD-1 were reported to be exhausted cells. It remains unknown what the role of CD4 T cells expressing PD-1 is and what the upstream regulating molecules of PD-1 in CD4 T cells are. The C57BL/6 mice were injected with

Indexed as

CD4-Positive T-LymphocytesHypoxia-Inducible Factor 1, alpha SubunitMalariaNFATC Transcription FactorsPlasmodium yoeliiProgrammed Cell Death 1 ReceptorAnimalsCytokinesMiceMice, Inbred C57BLSignal TransductionCytokinesHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitNfatc1 protein, mouseNFATC Transcription FactorsPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorCD4 T cellsHIF-1αNFATc1PD-1P. yoelii

Identifiers

PMID36091043
PMCPMC9449323
OpenAlexW4292877366

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.