ArticleFrontiers in medicine2022
Association between glucose-to-lymphocyte ratio and in-hospital mortality in intensive care patients with sepsis: A retrospective observational study based on Medical Information Mart for Intensive Care IV.
Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Association of the glucose-to-lymphocyte ratio with all-cause and cardiovascular disease mortality in U.S. adults: A population-based cohort study.Clinics (Sao Paulo, Brazil) · 2026Article
- Association between glucose-to-platelet ratio and all-cause mortality in critically ill patients with acute myocardial infarction: a retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Correlation between SHR and 28-day all-cause mortality risk in patients with spontaneous intracerebral hemorrhage.BMC neurology · 2026Article
- High glucose-to-lymphocyte ratio increases the risk of delirium and all-cause mortality in intensive care unit patients.Scientific reports · 2026Article
- Development and validation of a sepsis-specific systemic inflammation classification system for mortality prediction.Frontiers in medicine · 2026Article
- Association of glucose-lymphocyte ratio and short-term mortality in patients with sepsis complicated by ARDS during the acute phase: a multicenter retrospective cohort study.Frontiers in cellular and infection microbiology · 2026Observational
- Prognostic value of glucose-to-lymphocyte ratio for all-cause mortality and consciousness impairment in critically ill cerebrovascular disease patients.European journal of medical research · 2025Article
- Evaluating the role of glucose-to-lymphocyte ratio as a prognostic indicator in pediatric moderate to severe traumatic brain injury.European journal of medical research · 2025Article
- Development and validation of an interpretable machine learning model for early prediction in patients with diabetes and sepsis.Scientific reports · 2025Article
- Association between Glucose/lymphocytes Ratio and Contrast-Induced Acute Kidney Injury in Patients with Myocardial Infarction without Diabetes Mellitus.Arquivos brasileiros de cardiologia · 2025Article
- Association Between the Glucose-to-Lymphocyte Ratio and 28-Day Mortality in Patients with Mechanical Ventilation.Balkan medical journal · 2025Article
- Association between glucose-to-lymphocyte ratio and long-term mortality among women after coronary artery bypass grafting: filling gaps in female.BMC cardiovascular disorders · 2025Article
- Predictive value of hematologic indices on weaning from mechanical ventilation and 30-day mortality in patients with traumatic brain injury in an intensive care unit: A retrospective analysis of MIMIC-IV data.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- The Glucose-to-Lymphocyte Ratio Predicts All-cause Mortality and Cardiovascular Mortality in ST-Elevation Myocardial Infarction Patients: A Retrospective Study.Reviews in cardiovascular medicine · 2025Article
- Relationship between glucose to lymphocyte ratio and the first peritonitis episode in patients treated with peritoneal dialysis.Scientific reports · 2025Article
- Inflammation, glucose metabolism, and nutritional markers in relation to all-cause and cardiac mortality among initial hemodialysis patients: a multicenter cohort study.Frontiers in nutrition · 2025Article
- Article
- Systemic inflammation response index as a prognostic factor for patients with sepsis-associated acute kidney injury: a retrospective observational study.The Journal of international medical research · 2024Observational
- Association between alkaline phosphatase to albumin ratio and mortality among patients with sepsis.Scientific reports · 2024Article
- Association between lactate to hematocrit ratio and 30-day all-cause mortality in patients with sepsis: a retrospective analysis of the Medical Information Mart for Intensive Care IV database.Frontiers in medicine · 2024Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study aimed to evaluate the association between the glucose-to-lymphocyte ratio (GLR) and in-hospital mortality in intensive care unit (ICUs) patients with sepsis. Methods: This is a retrospective cohort study. Patients with sepsis from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database had their baseline data and in-hospital prognosis retrieved. Multivariable Cox regression analyses were applied to calculate adjusted hazard ratios (HR) with 95% confidence intervals (CI). Survival curves were plotted, and subgroup analyses were stratified by relevant covariates. To address the non-linearity relationship, curve fitting and a threshold effect analysis were performed. Results: Of the 23,901 patients, 10,118 patients with sepsis were included. The overall in-hospital mortality rate was 17.1% (1,726/10,118). Adjusted for confounding factors in the multivariable Cox regression analysis models, when GLR was used as a categorical variable, patients in the highest GLR quartile had increased in-hospital mortality compared to patients in the lowest GLR quartile (HR = 1.26, 95% CI: 1.15-1.38). When GLR was used as a continuous variable, each unit increase in GLR was associated with a 2% increase in the prevalence of in-hospital mortality (adjusted HR = 1.02, 95% CI: 1.01-1.03, Conclusion: There is a non-linear relationship between GLR and in-hospital mortality in intensive care patients with sepsis. A higher GLR in ICU patients is associated with in-hospital mortality in the United States. However, further research is needed to confirm the findings.
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