Evidence map›Paper›PMID 36093206›Full record

ArticleFrontiers in cellular and infection microbiology2022

Monomethylsulochrin isolated from biomass extract of

João Victor Silva-Silva, Rosiane Fernandes Moreira, Luciano Almeida Watanabe, Celeste da Silva Freitas de Souza, Daiana de Jesus Hardoim, Noemi Nosomi Taniwaki, Alvaro Luiz Bertho, Kerolain Faoro Teixeira, Arthur Ribeiro Cenci, Thiago Henrique Doring and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

João Victor Silva-SilvaLaboratory of Immunomodulation and Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
Rosiane Fernandes MoreiraPost-graduate Program in Chemistry, Federal University of Pará, Belém, PA, Brazil.
Luciano Almeida WatanabePost-graduate Program in Chemistry, Federal University of Pará, Belém, PA, Brazil.
Celeste da Silva Freitas de SouzaLaboratory of Immunomodulation and Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
Daiana de Jesus HardoimLaboratory of Immunomodulation and Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
Noemi Nosomi TaniwakiElectron Microscopy Center, Adolfo Lutz Institute, São Paulo, SP, Brazil.
Alvaro Luiz BerthoFlow Cytometry Core Facility, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, RJ, Brazil.
Kerolain Faoro TeixeiraDepartment of Exact Sciences and Education, Federal University of Santa Catarina, Blumenau, SC, Brazil.
Arthur Ribeiro CenciDepartment of Exact Sciences and Education, Federal University of Santa Catarina, Blumenau, SC, Brazil.
Thiago Henrique DoringDepartment of Exact Sciences and Education, Federal University of Santa Catarina, Blumenau, SC, Brazil.
José Wilmo da Cruz JúniorDepartment of Exact Sciences and Education, Federal University of Santa Catarina, Blumenau, SC, Brazil.
Aldo Sena de OliveiraDepartment of Exact Sciences and Education, Federal University of Santa Catarina, Blumenau, SC, Brazil.
Patrícia Santana Barbosa MarinhoPost-graduate Program in Chemistry, Federal University of Pará, Belém, PA, Brazil.
Kátia da Silva CalabreseLaboratory of Immunomodulation and Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
Andrey Moacir do Rosario MarinhoPost-graduate Program in Chemistry, Federal University of Pará, Belém, PA, Brazil.
Fernando Almeida-SouzaLaboratory of Immunomodulation and Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz · BRUniversidade Federal de Santa Catarina · BRUniversidade Federal do Pará · BRInstituto Adolfo Lutz · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leishmaniasis represents a serious world health problem, with 1 billion people being exposed to infection and a broad spectrum of clinical manifestations with a potentially fatal outcome. Based on the limitations observed in the treatment of leishmaniasis, such as high cost, significant adverse effects, and the potential for drug resistance, the aim of the present study was to evaluate the leishmanicidal activity of the compounds pseurotin A and monomethylsulochrin isolated from the biomass extract of

Indexed as

Antiprotozoal AgentsLeishmaniaLeishmania mexicanaLeishmaniasisAnimalsAspergillusBiomassHumansMiceMice, Inbred BALB CMolecular Docking SimulationPlant ExtractsAntiprotozoal AgentsPlant ExtractsADMETCYP51electron microscopyflow cytometryLeishmania amazonensismitochondrial membrane potentialmonomethylsulochrin

Identifiers

PMID36093206
PMCPMC9452909
OpenAlexW4293018366

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.