ReviewJournal of Alzheimer's disease : JAD2022
Cognitive Resilience in Brain Health and Dementia Research.
Review in Journal of Alzheimer's disease : JAD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Asymptomatic Versus Symptomatic Alzheimer's Disease Neuropathology: A Systematic Review of Differences Reported in Post-Mortem Studies.Neuropathology and applied neurobiology · 2026Pooled it
- Defining and Measuring Cognitive Decline and Clinical Relevance.Neurology and therapy · 2026Review
- Long-Term Cognitive and Functional Outcomes of Anesthesia and Surgery in Patients with Dementia.Healthcare (Basel, Switzerland) · 2026Review
- Effects of a Yoga Exercise Program on Cognitive Distortion, Communication Skills, Intolerance of Uncertainty, and Psychological Characteristics Among Probationary Employees.Behavioral sciences (Basel, Switzerland) · 2026Article
- The emergence of neuropsychiatric symptoms in preclinical Alzheimer's disease: An emotion regulation perspective.Neuron · 2026Review
- Associations between self-reported change in lifestyle behaviors and brain health: Findings from the Healthy Brain Initiative.Journal of Alzheimer's disease : JAD · 2026Article
- Migration Effects on Cognition: Protocol for the Aging in Kerala Americans Research Study.JMIR research protocols · 2026Article
- Advancing brain health equity with Indigenous peoples: A critical imperative.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Exploring cortical excitability modulation to promote cognitive resilience in aging: an rTMS study protocol.Frontiers in human neuroscience · 2026Article
- Sleep duration promotes resistance and resilience to tau in older women at risk for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The role of bilingualism on functional decline and neurodegeneration in distinct ADRD clinical syndromes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Article
- Living in a 20-min neighborhood and brain health and resilience in older adults: The Healthy Brain Initiative.Health & place · 2025Article
- Cognitive reserve is associated with education, social determinants, and cognitive outcomes among older American Indians in the Strong Heart Study.Communications psychology · 2025Article
- Association between physical activity and cognitive function in post-menopausal women with high parity: the chain-mediating effects of nutritional status and depression.BMC women's health · 2025Article
- AI-enabled resilience modeling for brain health.Frontiers in molecular medicine · 2025Review
- From frailty to resilience: exploring adaptive capacity and reserve in older adults-a narrative review.Frontiers in aging · 2025Review
- Cortical excitability and the aging brain: toward a biomarker of cognitive resilience.Frontiers in psychology · 2025Article
- Challenges to identifying risk versus protective factors in Alzheimer's disease.Nature medicine · 2024Article
- APOE ε4 carrier status moderates the effect of lifestyle factors on cognitive reserve.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
With the expected rise in Alzheimer's disease and related dementias (ADRD) in the coming decades due to the aging population and a lack of effective disease-modifying treatments, there is a need for preventive strategies that may tap into resilience parameters. A wide array of resilience strategies has been proposed including genetics, socioeconomic status, lifestyle modifications, behavioral changes, and management of comorbid disease. These different strategies can be broadly classified as distinguishing between modifiable and non-modifiable risk factors, some of which can be quantified so that their clinical intervention can be effectively accomplished. A clear shift in research focus from dementia risk to addressing disease resistance and resilience is emerging that has provided new potential therapeutic targets. Here we review and summarize the latest investigations of resilience mechanisms and methods of quantifying resilience for clinical research. These approaches include identifying genetic variants that may help identify novel pathways (e.g., lipid metabolism, cellular trafficking, synaptic function, inflammation) for therapeutic treatments and biomarkers for use in a precision medicine-like regimen. In addition, innovative structural and molecular neuroimaging analyses may assist in detecting and quantifying pathological changes well before the onset of clinical symptoms setting up the possibility of primary and secondary prevention trials. Lastly, we summarize recent studies demonstrating the study of resilience in caregivers of persons living with dementia may have direct and indirect impact on the quality of care and patient outcomes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.