Evidence map›Paper›PMID 36095049›Full record

ArticleDiabetes2022

Plasma Phospholipid Monounsaturated Fatty Acids and Gestational Diabetes Mellitus: A Longitudinal Study in the NICHD Fetal Growth Studies-Singletons Cohort.

Kit Ying Tsoi, Yeyi Zhu, Jing Wu, Qi Sun, Stefanie N Hinkle, Ling-Jun Li, Zhen Chen, Natalie L Weir, Michael Y Tsai, Ronald C W Ma and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Kit Ying TsoiDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0002-1331-0417
Yeyi ZhuDivision of Research, Kaiser Permanente Northern California, Oakland, CA.ORCID 0000-0002-7296-738X
Jing WuGlotech, Inc., Rockville, MD.
Qi SunDepartments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Stefanie N HinkleDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Ling-Jun LiDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0003-0685-3189
Zhen ChenDivision of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
Natalie L WeirDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Michael Y TsaiDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Ronald C W MaDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0002-1227-803X
Cuilin ZhangDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Chinese University of Hong Kong · HKNational University of Singapore · SGUniversity of Minnesota · USBrigham and Women's Hospital · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USKaiser Permanente · USUniversity of Pennsylvania · US

Funding

NICHD NIH HHS HHSN275200800002CNICHD NIH HHS HHSN275200800002INICHD NIH HHS HHSN275200800003CNICHD NIH HHS HHSN275200800003INICHD NIH HHS HHSN275200800012CNICHD NIH HHS HHSN275200800013CNICHD NIH HHS HHSN275200800014CNICHD NIH HHS HHSN275200800028CNICHD NIH HHS HHSN275201000001GNICHD NIH HHS HHSN275201000001ZNICHD NIH HHS HHSN275201000009CNIDDK NIH HHS K01 DK120807
6 · The paper itself

Abstract

Fatty acids (FAs) have been implicated in the development of gestational diabetes mellitus (GDM), but the role of monounsaturated FAs (MUFAs) remains understudied. We investigated the associations of plasma phospholipid MUFAs in early to mid-pregnancy with cardiometabolic biomarkers and GDM risk. From the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies-Singletons cohort (2009-2013), we identified 107 women with GDM according to Carpenter and Coustan criteria and 214 control participants without GDM matched (2:1) on age, race/ethnicity, and gestational week (GW) of blood collection. MUFAs were measured at 10-14, 15-26, 23-31, and 33-39 GWs by gas chromatography mass spectrometry. We found that the concentration of total 18:1 MUFAs was significantly lower among women with GDM than those without GDM at 15-26 GWs. Each SD increment in the level of total 18:1 MUFAs was associated with a 40% lower risk of GDM at 15-26 GWs. Moreover, each SD increment in vaccenic acid (18:1n-7) levels at 10-14 and 15-26 GWs were associated with a 36% and 45% lower risk of GDM, respectively. Our extensive assessments of MUFAs advance our understanding of the unique associations of FA composition with GDM risk, suggesting the potentially beneficial role of MUFAs in GDM pathophysiology.

Indexed as

Diabetes, GestationalChildFatty AcidsFatty Acids, MonounsaturatedFemaleFetal DevelopmentHumansLongitudinal StudiesNational Institute of Child Health and Human Development (U.S.)PhospholipidsPregnancyUnited StatesFatty AcidsFatty Acids, MonounsaturatedPhospholipids

Identifiers

PMID36095049
PMCPMC9750941
OpenAlexW4295605419

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.