Evidence map›Paper›PMID 36096340›Full record

ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2023

The Associations of Aortic Valve Sclerosis, Aortic Annular Increased Reflectivity, and Mitral Annular Calcification with Subsequent Aortic Stenosis in Older Individuals: Findings from the Cardiovascular Health Study.

Eddy Barasch, John S Gottdiener, William Tressel, Traci M Bartz, Petra Buzkova, Daniele Massera, Christopher deFilippi, Mary L Biggs, Bruce M Psaty, Jorge R Kizer and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Eddy BaraschDepartment of Research and Education, St. Francis Hospital/SUNY at Stony Brook, Roslyn, New York. Electronic address: eddy.barasch@chsli.org.
John S GottdienerDepartment of Medicine (Cardiology), University of Maryland School of Medicine, Baltimore, Maryland.
William TresselDepartment of Biostatistics, University of Washington, Seattle, Washington.
Traci M BartzDepartment of Biostatistics, University of Washington, Seattle, Washington.
Petra BuzkovaDepartment of Biostatistics, University of Washington, Seattle, Washington.
Daniele MasseraLeon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York.
Christopher deFilippiDivision of Cardiology, Inova Health System, Falls Church, Virginia.
Mary L BiggsDepartment of Biostatistics, University of Washington, Seattle, Washington.
Bruce M PsatyDepartments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington and Kaiser Permanente Washington Health Research Institute, Seattle, Washington.
Jorge R KizerCardiology Section, San Francisco Veterans Affairs Health Care System and Departments of Medicine, Epidemiology, and Biostatistics, University of California, San Francisco, San Francisco, California.
David OwensDivision of Cardiology, University of Washington, Seattle, Washington.
University of Washington · USInova Health System · USKaiser Permanente Washington Health Research Institute · USNew York University · USSt. Francis Hospital · USUniversity of California, San Francisco · USUniversity of Maryland, Baltimore · US

Funding

Exceptional aging: 12 year trajectories to functionR01AG023629 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2004 to 2005
$2.6M
CHS Events Follow-up StudyU01HL080295 · UNIVERSITY OF WASHINGTON · 2005 to 2005
$1.1M
CORONARY HEART DISEASE &STROKE IN THE ELDERLYN01HC085080 · WAKE FOREST UNIVERSITY · 1988 to 2000
–
CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84N01HC085081 · JOHNS HOPKINS UNIVERSITY · 1988 to 2000
–
CHS-Transition Phase -268055222N01HC055222 · University of Washington · 2005 to 2005
–
CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84N01HC085083 · UNIVERSITY OF CALIFORNIA DAVIS · 1988 to 1999
–
CENTRAL BLOOD ANALYSIS LABORATORY FOR CHSN01HC085086 · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · 1988 to 2000
–
CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84N01HC085082 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1988 to 2000
–
CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65 TO 84N01HC085079 · UNIVERSITY OF WASHINGTON · 1988 to 2005
–
NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG023629
6 · The paper itself

Abstract

backgroundAlthough aortic valve sclerosis (AVS) is well described as preceding aortic stenosis (AS), the associations of AS with antecedent mitral annular calcification (MAC) and aortic annular increased reflectivity (AAIR) have not been characterized. In a population-based prospective study, the authors evaluated whether MAC, AAIR, and AVS are associated with the risk for incident AS.

methodsAmong participants of the Cardiovascular Health Study free of AS at the 1994-1995 visit, the presence of MAC, AAIR, AVS, and the combination of all three was evaluated in 3,041 participants. Cox proportional-hazards regression was used to assess the association between the presence of calcification and the incidence of moderate or severe AS in three nested models adjusting for factors associated with atherosclerosis and inflammation both relevant to the pathogenesis of AS.

resultsOver a median follow-up period of 11.5 years (interquartile range, 6.7-17.0 years), 110 cases of incident moderate or severe AS were ascertained. Strong positive associations with incident moderate or severe AS were found for all calcification sites after adjustment for the main model covariates: AAIR (hazard ratio [HR], 2.90; 95% CI, 1.95-4.32; P < .0005), AVS (HR, 2.20; 95% CI, 1.44-3.37; P < .0005), MAC (HR, 1.67; 95% CI, 1.14-2.45; P = .008), and the combination of all three (HR, 2.50; 95% CI, 1.65-3.78; P < .0005). In a secondary analysis, the risk for AS increased with the number of sites at which calcification was present.

conclusionsIn a large cohort of community-dwelling elderly individuals, there were strong associations between each of AAIR, AVS, MAC, and the combination of the three and incident moderate or severe AS. The novel finding that AAIR had a particularly strong association with incident AS, even after adjusting for other calcification sites, suggests its value in identifying individuals at risk for AS and potential inclusion in routine assessment by transthoracic echocardiography.

Indexed as

Aortic Valve StenosisCalcinosisHeart Valve DiseasesMitral Valve StenosisAgedAortic ValveHumansProspective StudiesSclerosisAortic annular increased reflectivityAortic valve sclerosisIncident aortic stenosisMitral annular calcification

Identifiers

PMID36096340
PMCPMC9822849
OpenAlexW4295296139

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.