Evidence map›Paper›PMID 36096454›Full record

ReviewCurrent problems in cardiology2023

Associations between Alcohol Consumption and HDL Subspecies Defined by ApoC3, ApoE and ApoJ: the Cardiovascular Health Study.

Trine L Wilkens, Helle Sørensen, Majken K Jensen, Jeremy D Furtado, Lars O Dragsted, Kenneth J Mukamal

Open access · hybridAbstract readReview
In one paragraph

Review in Current problems in cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Trine L WilkensFrom Department of Nutrition, Exercise and Sports, Section for Preventive and Clinical Nutrition, University of Copenhagen, Frederiksberg, Denmark. Electronic address: tlevrings@gmail.com.
Helle SørensenFrom Department of Mathematical Sciences, Data Science Lab, University of Copenhagen, Copenhagen East, Denmark.
Majken K JensenFrom Department of Nutrition, Harvard T.H. Chan School of Public Health, MA; From Department of Public Health, Section of Epidemiology, University of Copenhagen, Copenhagen K, Denmark.
Jeremy D FurtadoFrom Department of Nutrition, Harvard T.H. Chan School of Public Health, MA.
Lars O DragstedFrom Department of Nutrition, Exercise and Sports, Section for Preventive and Clinical Nutrition, University of Copenhagen, Frederiksberg, Denmark.
Kenneth J MukamalFrom Department of Nutrition, Harvard T.H. Chan School of Public Health, MA; From Beth Israel Deaconess Medical Center, Division of General Medicine Research Section, Boston, MA.
University of Copenhagen · DKBeth Israel Deaconess Medical Center · USHarvard University · US

Funding

Wake Forest Field CenterU10AA025286 · NIAAA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GROBBEE, DIEDERICK · 2016 to 2017
$11.4M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CARDIOVASCULAR HEALTH STUDY (CHS) - TASK AREA C, STUDY CLOSEOUT75N92021D00006 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE · 2021 to 2024
$8.4M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
Novel lipoprotein particles, brain abnormalities, and risk of dementia and strokeR01NS089638 · NINDS · HARVARD SCHOOL OF PUBLIC HEALTH · PI JENSEN, MAJKEN KAROLINE · 2015 to 2018
$2.6M
Non-esterified Fatty Acids and Chronic Pain in Older AdultsK24AG065525 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MUKAMAL, KENNETH JAY · 2020 to 2024
$1.0M
CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84N01HC085083 · HC · UNIVERSITY OF CALIFORNIA DAVIS · PI ROBBINS, JOHN A · 1988 to 1999
–
CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65 TO 84N01HC085079 · HC · UNIVERSITY OF WASHINGTON · 1988 to 2005
–
CHS-Transition Phase -268055222-268055222N01HC055222 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 2005 to 2006
–
CENTRAL BLOOD ANALYSIS LABORATORY FOR CHSN01HC085086 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1988 to 2000
–
CORONARY HEART DISEASE &STROKE IN THE ELDERLYN01HC085080 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1988 to 2000
–
NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIAAA NIH HHS U10 AA025286NIA NIH HHS K24 AG065525NIA NIH HHS R01 AG023629NINDS NIH HHS R01 NS089638
6 · The paper itself

Abstract

Alcohol consumption increases circulating high-density lipoprotein cholesterol (HDL-C), but HDL protein cargo may better reflect HDL function. This study examined the associations between alcohol intake and HDL subspecies containing or lacking apoC3, apoE, and apoJ in a well-phenotyped cohort. We performed a cross-sectional analysis of 2092 Cardiovascular Health Study participants aged 70 or older with HDL subspecies measured in stored specimens from 1998 to 1999. Associations between alcohol intake and apoA1 defined HDL subspecies lacking or containing apoC3, apoE, and apoJ, and circulating levels of total apoA1, apoC3, apoE, and apoJ were examined. HDL subspecies lacking and containing apoC3, apoE, and apoJ were all positively associated with alcohol intake, with ∼1% per additional drink per week or ∼7% per additional drink per day (subspecies without the apolipoproteins, P ≤ 2 × 10

Indexed as

Alcohol DrinkingApolipoproteinsApolipoprotein A-IApolipoprotein C-IIIApolipoproteins EClusterinCross-Sectional StudiesHumansMaleAPOA1 protein, humanAPOC3 protein, humanApoE protein, humanApolipoprotein A-IApolipoprotein C-IIIApolipoproteinsApolipoproteins ECLU protein, humanClusterin

Identifiers

PMID36096454
PMCPMC9691554
OpenAlexW4295129798

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.