ArticleNeuropsychiatric disease and treatment2022
Predictors of Early Neurological Deterioration and Functional Outcome in Acute Ischemic Stroke: The Importance of Large Artery Disease, Hyperglycemia and Inflammatory Blood Biomarkers.
Article in Neuropsychiatric disease and treatment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk factors for unexplained early neurological deterioration after intravenous thrombolysis: a meta-analysis.Neurosciences (Riyadh, Saudi Arabia) · 2025Pooled it
- Onset to Treatment Time and Early Neurological Deterioration of Dual Antiplatelet Therapy Versus Alteplase in Minor Stroke.Journal of the American Heart Association · 2025Trial
- Systemic immune-inflammation index predicts hemorrhagic transformation after endovascular therapy for ischemic stroke.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Development and validation of a nomogram to predict early neurological deterioration in patients with acute ischemic stroke and type 2 diabetes mellitus: the pivotal role of glycemic variability and thrombo-inflammation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Interleukin‑6 and ischemic stroke: From mechanisms to clinical prospects (Review).Molecular medicine reports · 2026Review
- Prediction model for early neurological deterioration in large artery atherosclerotic stroke.Frontiers in neurology · 2026Article
- Incidence, outcomes and risk factors of rebound neurological deterioration after initial improvement following intravenous thrombolysis: a retrospective cohort study.Frontiers in aging neuroscience · 2026Article
- Predictive value of serum homocysteine and potassium ion for short-term prognosis of patients with acute cerebral infarction following intravenous thrombolysis with recombinant tissue plasminogen activator.Thrombosis journal · 2025Article
- Article
- Association between impaired brachial flow-mediated dilation and early neurological deterioration in acute ischemic stroke: a retrospective analysis.BMC neurology · 2025Article
- Analyzing the serum biochemical factors that influence early neurological deterioration in ischemic Stroke patients and developing a nomogram prediction model.Journal of medical biochemistry · 2025Article
- Early Neurological Deterioration following acute stroke: association with reperfusion therapies and National Institutes Of Health Stroke Scale score.Frontiers in stroke · 2025Article
- Early neurological deterioration in patients with minor stroke: A single-center study conducted in Vietnam.PloS one · 2025Observational
- Optimal 24-h NIHSS threshold of ⩽9 predicts 90-day outcomes after posterior circulation thrombectomy: ANGEL-ACT Registry Insights.Therapeutic advances in neurological disorders · 2025Article
- Study of Biochemical Predictors of Early Neurological Deterioration in Ischemic Stroke in a Tertiary Care Hospital.Cureus · 2024Article
- Article
- Inflammatory marker profiles and in-hospital neurological deterioration in patients with acute minor ischemic stroke.CNS neuroscience & therapeutics · 2024Article
- Seasonal Variations in Stroke and a Comparison of the Predictors of Unfavorable Outcomes among Patients with Acute Ischemic Stroke and Cardioembolic Stroke.Biomedicines · 2024Article
- Observational
- Predictive role of neuron-specific enolase and S100-β in early neurological deterioration and unfavorable prognosis in patients with ischemic stroke.Open medicine (Warsaw, Poland) · 2024Article
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5 authors.
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Abstract
Background: Early neurological deterioration (END) in acute ischemic stroke (AIS) can be associated with poor outcome. The aim of this study was to investigate the association between infarction subtypes, biomarkers and END, and to identify patients with risk of unfavorable functional outcome. Materials and Methods: This prospective study enrolled 101 patients with AIS. Neurological status was evaluated according to NIHSS at acute onset, on days 2, 3, and 90. END was defined as ≥2-point increase of NIHSS within 72 hours. Functional outcome was assessed using NIHSS and the modified Rankin Scale (mRS) at day 90. Results: END was observed in 20, 8%. Patients with large artery disease had higher risk of developing END compared with patients with cardioembolism or small vessel disease (p <0.01). Significant higher blood glucose level and leukocytes were observed in the END group. Patients with END had higher scores of mRS at day 90 (p <0.01). Levels of NSE, IL-6, hsCRP and NT-proBNP were higher in the patients with unfavorable compared with favorable functional outcome. Conclusion: Large artery disease, high blood glucose and leukocytes levels are associated with END. Elevated levels of blood markers NSE, IL-6, HsCRP and NT-proBNP indicate poor functional outcome at 90 days after AIS. These patients must be identified and be offered treatment immediately in order to improve the functional outcome after AIS.
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