Evidence map›Paper›PMID 36100318›Full record

Trial reportOpen heart2022

Effect of cocoa (

Naveen Anand Seecheran, Darin Sukha, Kathryn Grimaldos, Gabriella Grimaldos, Srivane Richard, Aleena Ishmael, Ceylon Gomes, Lirmala Kampradi, Rajeev Seecheran, Valmiki Seecheran and 9 more

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Open heart, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04554901 (The Effect of Cocoa on Platelet Function Profiles in Patients With Stable Coronary Artery Disease in Trinidad and Tobago), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04554901 nacompletednot on this map

The Effect of Cocoa on Platelet Function Profiles in Patients With Stable Coronary Artery Disease in Trinidad and Tobago: The ECLAIR Study

TypeinterventionalSponsorThe University of The West IndiesRan2020 to 2022Enrolled25ConditionsPlatelet DysfunctionArmsCocoa
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Naveen Anand SeecheranClinical Medical Sciences, The University of the West Indies, Saint Augustine, Trinidad and Tobago nseecheran@gmail.com.ORCID 0000-0002-7779-0181
Darin SukhaCocoa Research Centre, The University of the West Indies, Saint Augustine, Trinidad and Tobago.
Kathryn GrimaldosDepartment of Medicine, North Central Regional Health Authority, Champ Fleurs, Trinidad and Tobago.
Gabriella GrimaldosDepartment of Medicine, North Central Regional Health Authority, Champ Fleurs, Trinidad and Tobago.
Srivane RichardDepartment of Medicine, North Central Regional Health Authority, Champ Fleurs, Trinidad and Tobago.
Aleena IshmaelDepartment of Medicine, North Central Regional Health Authority, Champ Fleurs, Trinidad and Tobago.
Ceylon GomesDepartment of Medicine, North Central Regional Health Authority, Champ Fleurs, Trinidad and Tobago.
Lirmala KampradiDepartment of Medicine, North Central Regional Health Authority, Champ Fleurs, Trinidad and Tobago.
Rajeev SeecheranDepartment of Medicine, University of Kansas Medical Center, Wichita, Kansas, USA.
Valmiki SeecheranDepartment of Medicine, North Central Regional Health Authority, Champ Fleurs, Trinidad and Tobago.
Lakshmipathi PeramDepartment of Medicine, North Central Regional Health Authority, Champ Fleurs, Trinidad and Tobago.
Darren DookeeramDepartment of Medicine, North Central Regional Health Authority, Champ Fleurs, Trinidad and Tobago.
Stanley GiddingsClinical Medical Sciences, The University of the West Indies, Saint Augustine, Trinidad and Tobago.
Sherry SandyClinical Medical Sciences, The University of the West Indies, Saint Augustine, Trinidad and Tobago.
Anil RamlackhansinghClinical Medical Sciences, The University of the West Indies, Saint Augustine, Trinidad and Tobago.
Sadi RazaCardiology Division, HeartPlace, Dallas, Texas, USA.
Pathmanathan UmaharanCocoa Research Centre, The University of the West Indies, Saint Augustine, Trinidad and Tobago.
Antonio Tello-MontoliuCardiology Division, Universidad de Murcia, Murcia, Spain.
David SchneiderCardiology Division, University of Vermont Medical Center, Burlington, Vermont, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis prospective pharmacodynamic nutraceutical study assessed the effect of a 1-week trial of 30 g/day of 65% cocoa (dark chocolate) (

methodsPatients with stable coronary artery disease (CAD) (n=20) who were on maintenance dual antiplatelet therapy of aspirin (ASA) 81 mg/day and clopidogrel 75 mg/day were recruited. Platelet function was evaluated with the VerifyNow P2Y

resultsCocoa augmented the inhibitory effect of clopidogrel, demonstrated by a reduction of 11.9% (95% CI 5.7% to 18.0%, p value 0.001), significantly decreasing the PRU by 26.85 (95% CI 12.22 to 41.48, p value 0.001). The inhibitory effect of ASA was not impacted by cocoa, reflected by a non-significant reduction in ARU of 17.65 (95% CI 21.00 to 56.3, p value 0.351). No patients experienced any serious adverse events.

conclusionsCocoa augmented the inhibitory effect of clopidogrel but not ASA. This nutraceutical study could be potentially informative and applicable for patients with stable CAD. Further long-term studies are required to confirm these exploratory findings. TRIAL REGISTRATION NUMBER: NCT04554901.

Indexed as

CacaoChocolateCoronary Artery DiseaseAspirinClopidogrelHumansPilot ProjectsPlatelet Aggregation InhibitorsProspective StudiesTiclopidineAspirinClopidogrelPlatelet Aggregation InhibitorsTiclopidineDrug InteractionsEpidemiologyPharmacology, Clinical

Identifiers

PMID36100318
PMCPMC9472200

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.