Evidence map›Paper›PMID 36100548›Full record

ArticleJournal of geriatric oncology2023

Advance care planning in older patients with acute myeloid leukemia and myelodysplastic syndromes.

Marissa LoCastro, Chandrika Sanapala, Jason H Mendler, Sally Norton, Rachelle Bernacki, Thomas Carroll, Heidi Klepin, Erin Watson, Jane Liesveld, Eric Huselton and 5 more

Registry-linked trialAbstract read
In one paragraph

Article in Journal of geriatric oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05875805 (A Telehealth Advance Care Planning Intervention for Older Patients With Myeloid Malignancies), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05875805 narecruitingnot on this mapstarted 2024, after this paper: background citation

A Telehealth Advance Care Planning Intervention for Older Patients With Myeloid Malignancies: A Pilot Randomized Controlled Trial

TypeinterventionalSponsorUniversity of RochesterRan2024 to 2027Enrolled207ConditionsMyeloid Malignancy, Acute Myeloid Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative NeoplasmArmsTelehealth Serious Illness Care Program, Education Control
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Exploring Patients' Perceptions of an Advance Care Planning Intervention in the Emergency Department: A Qualitative Study.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2025
    Trial
  3. Symptom burden and palliative care in patients with hematologic malignancies: a single-center experience.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marissa LoCastroSchool of Medicine and Dentistry, University of Rochester, Rochester, NY, USA. Electronic address: Marissa_locastro@urmc.rochester.edu.
Chandrika SanapalaDivision of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: Chandrika.sanapala@burrell.edu.
Jason H MendlerDivision of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: Jason_mendler@urmc.rochester.edu.
Sally NortonSchool of Nursing, University of Rochester, Rochester, NY, USA. Electronic address: Sally_norton@urmc.rochester.edu.
Rachelle BernackiDepartment of Palliative Care, Harvard Medical School, Boston, MA, USA. Electronic address: RachelleE_Bernacki@DFCI.HARVARD.EDU.
Thomas CarrollDivision of General Medicine and Palliative Care, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: Thomas_carroll@urmc.rochester.edu.
Heidi KlepinDepartment of Hematology/Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: hklepin@wakehealth.edu.
Erin WatsonPrinceton University, NJ, USA. Electronic address: eewatson@princeton.edu.
Jane LiesveldDivision of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: Jane_liesveld@urmc.rochester.edu.
Eric HuseltonDivision of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: Eric_huselton@urmc.rochester.edu.
Kristen O'DwyerDivision of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: Kristen_odwyer@urmc.rochester.edu.
Andrea BaranDepartment of Biostatistics and Computational Biology, University of Rochester, New York, USA. Electronic address: Andrea_baran@urmc.rochester.edu.
Marie FlannerySchool of Nursing, University of Rochester, Rochester, NY, USA. Electronic address: Marie_flannery@urmc.rochester.edu.
Benzi M KlugerDivision of General Medicine and Palliative Care, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA; Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: Benzi_kluger@urmc.rochester.edu.
Kah Poh LohDivision of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: Kahpoh_loh@urmc.rochester.edu.

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Geriatric Oncology Research Infrastructure to Improve Clinical CareR33AG059206 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI WILLIAM DALE, Heidi Diana Klepin · 2020 to 2026
$5.1M
Mentoring the Next Generation of Geriatric Oncology Researchers in Patient-Oriented Research to Improve the Care of Older Adults with CancerK24AG055693 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI WILLIAM DALE · 2018 to 2026
$1.4M
A novel mobile health exercise intervention for older patients with myeloid neoplasmsR00CA237744 · NCI · UNIVERSITY OF ROCHESTER · PI LOH, KAH POH · 2021 to 2023
$747k
Advancing Palliative Care for Older Adults Affected by Neurodegenerative Disease: Parkinsons disease, Alzheimers disease and Related DementiasK02AG062745 · NIA · UNIVERSITY OF ROCHESTER · PI KLUGER, BENZI M · 2020 to 2024
$711k
Geriatric Oncology Research Infrastructure to Improve Clinical CareR21AG059206 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI DALE, WILLIAM, MOHILE, SUPRIYA G. · 2018 to 2019
$478k
A Novel Mobile Health Exercise Intervention for Older Patients with Myeloid NeoplasmsK99CA237744 · NCI · UNIVERSITY OF ROCHESTER · PI LOH, KAH POH · 2019 to 2020
$385k
NCI NIH HHS K99 CA237744NCI NIH HHS R00 CA237744NCI NIH HHS UG1 CA189961NIA NIH HHS K02 AG062745NIA NIH HHS K24 AG055693NIA NIH HHS R21 AG059206NIA NIH HHS R33 AG059206
6 · The paper itself

Abstract

introductionOlder patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) have worse survival rates compared to younger patients, and experience more intense inpatient healthcare at the end of life (EOL) compared to patients with solid tumors. Advance care planning (ACP) has been shown to limit aggressive and burdensome care at EOL for patients with AML and MDS. The purpose of this study was to better understand ACP from the perspective of clinicians, older patients with AML and MDS, and their caregivers. MATERIALS AND

methodsWe conducted semi-structured interviews with 45 study participants. Interviews were audio-recorded and transcribed. Open coding and focused content analysis were used to organize data and develop and contextualize categories and subcategories.

resultsGuided by our specific aims, we developed four themes: (1) The language of ACP and medical order for life-sustaining treatment (MOLST) does not resonate with patients, (2) There is no uniform consensus on when ACP is currently happening, (3) Oncology clinician-perceived barriers to ACP (e.g., patient discomfort, patient lack of knowledge, and lack of time), and (4) Patients felt that they are balancing fear and hope when navigating their AML or MDS diagnosis. DISCUSSION: The results of this study can be used to develop interventions to promote serious illness conversations for patients with AML and MDS and their caregivers to ensure that patient care aligns with patient values.

Indexed as

Advance Care PlanningLeukemia, Myeloid, AcuteMyelodysplastic SyndromesAgedDelivery of Health CareHumansAcute myeloid leukemiaAdvance care planningHematologic malignancyMyelodysplastic syndromesQualitative study

Identifiers

PMID36100548
PMCPMC9974785

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.