ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2022
Racial discrimination associates with lower cingulate cortex thickness in trauma-exposed black women.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Structural and social determinants of health shape the impact of neurodegeneration and cerebrovascular pathology on cognitive functioning in black adults.Social science & medicine (1982) · 2026Article
- Racism and alterations in brain structure and function: A narrative review of emerging neuroimaging evidence in racialized individuals.Cognitive, affective & behavioral neuroscience · 2026Review
- Associations between amygdala connectivity and experienced discrimination in children.bioRxiv : the preprint server for biology · 2026Article
- Neural reactivity to a racial trauma cue in an African American woman with alcohol use disorder and PTSD: Case report.Psychiatry research case reports · 2025Article
- Racial discrimination and anxiety in African American youth: Risk, resilience, and intervention.Journal of mood and anxiety disorders · 2025Review
- Influences of sex and gender on the associations between risk and protective factors, brain, and behavior.Biology of sex differences · 2024Review
- Racial and ethnic socioenvironmental inequity and neuroimaging in psychiatry: a brief review of the past and recommendations for the future.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Associations between experiences of discrimination, anxiety, and mood symptoms in Black women: Investigating the mediating role of attentional control.Journal of mood and anxiety disorders · 2024Article
- Population-level normative models reveal race- and socioeconomic-related variability in cortical thickness of threat neurocircuitry.Communications biology · 2024Article
- Racial Discrimination, Neural Connectivity, and Epigenetic Aging Among Black Women.JAMA network open · 2024Article
- The neurophysiological consequences of racism-related stressors in Black Americans.Neuroscience and biobehavioral reviews · 2024Review
- Article
- Civilian Moral Injury and Amygdala Functional Connectivity During Attention to Threat.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Greater socioenvironmental risk factors and higher chronic pain stage are associated with thinner bilateral temporal lobes.Brain and behavior · 2023Article
- Neighborhood Disadvantage and Neural Correlates of Threat and Reward Processing in Survivors of Recent Trauma.JAMA network open · 2023Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Racial discrimination (RD) has been consistently linked to adverse brain health outcomes. These may be due in part to RD effects on neural networks involved with threat appraisal and regulation; RD has been linked to altered activity in the rostral anterior cingulate cortex (rACC) and structural decrements in the anterior cingulum bundle and hippocampus. In the present study, we examined associations of RD with cingulate, hippocampus and amygdala gray matter morphology in a sample of trauma-exposed Black women. Eighty-one Black women aged 19-62 years were recruited as part of an ongoing study of trauma. Participants completed assessments of RD, trauma exposure, and posttraumatic stress disorder (PTSD), and underwent T1-weighted anatomical imaging. Cortical thickness, surface area and gray matter volume were extracted from subregions of cingulate cortex, and gray matter volume was extracted from amygdala and hippocampus, and entered into partial correlation analyses that included RD and other socio-environmental variables. After correction for multiple comparisons and accounting for variance associated with other stressors and socio-environmental factors, participants with more RD exposure showed proportionally lower cortical thickness in the left rACC, caudal ACC, and posterior cingulate cortex (ps < = 0.01). These findings suggest that greater experiences of RD are linked to compromised cingulate gray matter thickness. In the context of earlier findings indicating that RD produces increased response in threat neurocircuitry, our data suggest that RD may increase vulnerability for brain health problems via cingulate cortex alterations. Further research is needed to elucidate biological mechanisms for these changes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.