ArticleScience translational medicine2022
Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor.
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Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Loss of cold shock domain-containing protein E1 (CSDE1) function enhances mRNA stability of interleukin-6 and promotes malignant transformation in endometrial cancer cells.Cell communication and signaling : CCS · 2026Article
- CSDE1 promotes viral immune evasion through RNA-dependent and phosphorylation-modulated liquid-liquid phase separation.Nature communications · 2026Article
- Functional interrogation of candidate cis-regulatory elements at the LDLR locus.PLoS genetics · 2026Article
- ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR expression in the liver.Communications biology · 2025Article
- Genetic effects on chromatin accessibility uncover mechanisms of liver gene regulation and quantitative traits.Genome research · 2025Article
- Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening.Atherosclerosis · 2025Article
- Systematic interrogation of functional genes underlying cholesterol and lipid homeostasis.Genome biology · 2025Article
- Cold exposure and the cardiovascular system: from physiological adaptation to pathological risk.Frontiers in physiology · 2025Review
- TOMM40 regulates hepatocellular and plasma lipid metabolism via an LXR-dependent pathway.Molecular metabolism · 2024Article
- Berberine alters the gut microbiota metabolism and impairs spermatogenesis.Acta biochimica et biophysica Sinica · 2024Article
- CSDE1: a versatile regulator of gene expression in cancer.NAR cancer · 2024Article
- Post-translational regulation of the low-density lipoprotein receptor provides new targets for cholesterol regulation.Biochemical Society transactions · 2024Article
- Heparin Does Not Regulate Circulating Human PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) in a General Population-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- Rapid Multiplexed Flow Cytometric Validation of CRISPRi sgRNAs in Tissue Culture.Bio-protocol · 2023Article
- CRISPR screening in cardiovascular research.Frontiers in cell and developmental biology · 2023Review
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Authors and funding
17 authors at 7 institutions in 2 countries.
Geoffrey A SmithDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-1638-4219
Arun PadmanabhanDivision of Cardiology, UCSF Health, San Francisco, CA 94143, USA.
Bryan H LauCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-0028-722X
Akhil PampanaCardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-4167-0540
Li LiDepartment of Medicine and Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-7844-6120
Clara Y LeeDivision of Cardiology, UCSF Health, San Francisco, CA 94143, USA.ORCID 0000-0002-9402-4155
Angelo PeloneroGladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.ORCID 0000-0002-7684-3771
Tomohiro NishinoGladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.ORCID 0000-0002-3593-7368
Nandhini SadagopanDivision of Cardiology, UCSF Health, San Francisco, CA 94143, USA.
Vivian Q XiaDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-6540-3738
Rajan JainDepartment of Medicine and Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Pradeep NatarajanCardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0001-8402-7435
Roland S WuDivision of Cardiology, UCSF Health, San Francisco, CA 94143, USA.ORCID 0000-0002-8253-1192
Brian L BlackCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-6664-8913
Deepak SrivastavaGladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.ORCID 0000-0002-3480-5953
Kevan M ShokatDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0001-8590-7741
John S ChorbaDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-6397-6348
Gladstone Institutes · USUniversity of California, San Francisco · USBroad Institute · USSan Francisco General Hospital · USCalifornia Institute for Regenerative Medicine · USHoward Hughes Medical Institute · USPenn Center for AIDS Research · US
Funding
THREE DIMENSIONAL VORTEX LIKE REENTRY IN CORONARY PERFUSED VENTRICULAR WALLP01HL039707 · NHLBI · UPSTATE MEDICAL UNIVERSITY · PI JALIFE, JOSE S · 1990 to 2010
$19.0MCARDIOGENESIS--MOLECULAR MECHANISMSR01HL057181 · NHLBI · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI DEEPAK SRIVASTAVA · 1997 to 2026
$14.0MProject 3: Control of cardiac transcription by MEF2 and myocardinP01HL146366 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BLACK, BRIAN L · 2019 to 2023
$13.7MUsing genetic variation to study biology of blood lipids & coronary heart diseaseR01HL127564 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pradeep Natarajan, Gina Marie Peloso · 2015 to 2026
$7.3MRegulation of Chromatin Signaling in Heart Failure by the BRD4 Bromodomain Protein.R01HL127240 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MCKINSEY, TIMOTHY, SRIVASTAVA, DEEPAK · 2015 to 2022
$6.4MClonal hematopoiesis in the Womens Health Initiative Memory StudyR01HL148565 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ALEXANDER P REINER, Eric A. Whitsel · 2019 to 2026
$5.9MClonal hematopoiesis in humans: determinants of development and progressionR01HL148050 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE MITCHELL, NATARAJAN, PRADEEP · 2019 to 2022
$5.9MWhole genome sequences in individuals to comprehensively characterize the genetic mechanisms of dyslipidemiasR01HL142711 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Satoshi Koyama, Gina Marie Peloso · 2019 to 2026
$4.7MCSDE1 as a Post Transcriptional Regulator of the LDLR - Diversity SupplementR01HL159457 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHORBA, JOHN S · 2021 to 2024
$2.6MEXTRAMULAR RESEARCH FACILITIES CONSTRUCTIONC06RR018928 · NCRR · J. DAVID GLADSTONE INSTITUTES · PI MAHLEY, ROBERT W. · 2003 to 2003
$2.1MChemical Biology to Modulate PCSK9 and Treat AtherosclerosisR01HL146404 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHORBA, JOHN S · 2021 to 2024
$1.6MThe Role of BRD4 in Cardiac SpecificationR01HL139783 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI JAIN, RAJAN · 2019 to 2022
$1.6MMedical Research Council MC_PC_17228Medical Research Council MC_QA137853NCRR NIH HHS C06 RR018928NHLBI NIH HHS K08 HL124068NHLBI NIH HHS K08 HL157700NHLBI NIH HHS P01 HL039707NHLBI NIH HHS P01 HL146366NHLBI NIH HHS R01 HL057181NHLBI NIH HHS R01 HL127240NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R01 HL139783NHLBI NIH HHS R01 HL142711NHLBI NIH HHS R01 HL146404NHLBI NIH HHS R01 HL148050NHLBI NIH HHS R01 HL148565NHLBI NIH HHS R01 HL159457NHLBI NIH HHS R03 HL145259NIDDK NIH HHS R01 DK119621
Abstract
The low-density lipoprotein receptor (LDLR) controls cellular delivery of cholesterol and clears LDL from the bloodstream, protecting against atherosclerotic heart disease, the leading cause of death in the United States. We therefore sought to identify regulators of the LDLR beyond the targets of current therapies and known causes of familial hypercholesterolemia. We found that cold shock domain-containing protein E1 (CSDE1) enhanced hepatic
Indexed as
Cold-Shock ResponseProprotein Convertase 9AnimalsDNA-Binding ProteinsHumansMiceReceptors, LDLRNA-Binding ProteinsRNA, MessengerTranscription, GeneticCSDE1 protein, humanDNA-Binding ProteinsPCSK9 protein, humanProprotein Convertase 9Receptors, LDLRNA-Binding ProteinsRNA, Messenger
Identifiers
What Socratic holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.