Evidence map›Paper›PMID 36106782›Full record

ReviewJournal of clinical pharmacology2022

Fetal Arrhythmia Diagnosis and Pharmacologic Management.

Janette F Strasburger, Gretchen Eckstein, Mary Butler, Patrick Noffke, Annette Wacker-Gussmann

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in Journal of clinical pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03775954 (Fetal Electrophysiologic Abnormalities in High-risk Pregnancies Associated With Fetal Demise), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03775954 recruitingnot on this map

Fetal Electrophysiologic Abnormalities in High-risk Pregnancies Associated With Fetal Demise

TypeobservationalSponsorMedical College of WisconsinRan2018 to 2028Enrolled30ConditionsHigh Risk Pregnancy, Congenital Heart Disease, Fetal Hydrops, Twin Monochorionic Monoamniotic PlacentaArmsFetal Magnetocardiogram and Neonatal Electrocardiogram, Substudy only: Maternal/Infant Pharmacogenomic assessment postnatally
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Diagnosis, Risk Factors, and Management Principles of Fetal Premature Atrial Contractions.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Repurposing of NKA inhibitors ('cardiac glycosides'): a critical analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Diagnosis and Management of Fetal Arrhythmias in the Current Era.Journal of cardiovascular development and disease · 2024
    Review
  19. Article
  20. Unexplained fetal tachycardia: A case report.World journal of clinical cases · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Janette F StrasburgerDivision of Cardiology, Departments of Pediatrics and Biomedical Engineering, Children's Wisconsin, Herma Heart Institute, and Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0000-0002-6986-2544
Gretchen EcksteinDivision of Cardiology, Departments of Pediatrics and Biomedical Engineering, Children's Wisconsin, Herma Heart Institute, and Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Mary ButlerCollege of Nursing, University of Wisconsin-Oshkosh, Oshkosh, Wisconsin, USA.
Patrick NoffkeDivision of Cardiology, Departments of Pediatrics and Biomedical Engineering, Children's Wisconsin, Herma Heart Institute, and Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Annette Wacker-GussmannGerman Heart Center, Department of Congenital Heart Disease and Pediatric Cardiology Munich, Munchen, Bavaria, Germany.
Children's Hospital of Wisconsin · USDeutsches Herzzentrum München · DEUniversity of Wisconsin–Oshkosh · US

Funding

Optimized Signal Processing of Fetal MCG R01HL063174 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI WAKAI, RONALD T · 1999 to 2020
$8.4M
Fetal Electrophysiologic Abnormalities in High-risk Pregnancies Associated with Fetal DemiseR01HL143485 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI STRASBURGER, JANETTE F · 2018 to 2021
$2.5M
NHLBI NIH HHS R01 HL063174NHLBI NIH HHS R01 HL143485
6 · The paper itself

Abstract

One of the most successful achievements of fetal intervention is the pharmacologic management of fetal arrhythmias. This management usually takes place during the second or third trimester. While most arrhythmias in the fetus are benign, both tachy- and bradyarrhythmias can lead to fetal hydrops or cardiac dysfunction and require treatment under certain conditions. This review will highlight precise diagnosis by fetal echocardiography and magnetocardiography, the 2 primary means of diagnosing fetuses with arrhythmia. Additionally, transient or hidden arrhythmias such as bundle branch block, QT prolongation, and torsades de pointes, which can lead to cardiomyopathy and sudden unexplained death in the fetus, may also need pharmacologic treatment. The review will address the types of drug therapies; current knowledge of drug usage, efficacy, and precautions; and the transition to neonatal treatments when indicated. Finally, we will highlight new assessments, including the role of the nurse in the care of fetal arrhythmias. The prognosis for the human fetus with arrhythmias continues to improve as we expand our ability to provide intensive care unit-like monitoring, to better understand drug treatments, to optimize subsequent pregnancy monitoring, to effectively predict timing for delivery, and to follow up these conditions into the neonatal period and into childhood. Coordinated initiatives that facilitate clinical fetal research are needed to address gaps in knowledge and to facilitate fetal drug and device development.

Indexed as

Fetal DiseasesArrhythmias, CardiacChildElectrocardiographyFemaleFetusHumansInfant, NewbornPregnancyPrognosisantiarrhythmic drugsarrhythmiacongenital heart blockfetal arrhythmiafetal echocardiographyfetal magnetocardiographyfetal pharmacologyfetal tachycardialong QT syndrometorsades de pointes

Identifiers

PMID36106782
PMCPMC9543141
OpenAlexW4295901343

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.