Evidence map›Paper›PMID 36112124›Full record

ArticleACS applied materials & interfaces2022

Poly(cannabinoid)s: Hemp-Derived Biocompatible Thermoplastic Polyesters with Inherent Antioxidant Properties.

Robert Daniels, Erick Orozco Morato, Omer A Yassin, Jiahao Mao, Zeynep Mutlu, Mayank Jain, Joseph Valenti, Mukerrem Cakmak, Lakshmi S Nair, Gregory A Sotzing

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Robert DanielsDepartment of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States.ORCID 0000-0003-1114-5515
Erick Orozco MoratoThe Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health Center, Farmington, Connecticut 06030, United States.
Omer A YassinDepartment of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States.
Jiahao MaoSchool of Materials Engineering, Purdue University, West Lafayette, Indiana 47906, United States.
Zeynep MutluSchool of Materials Engineering, Purdue University, West Lafayette, Indiana 47906, United States.ORCID 0000-0002-8146-2666
Mayank JainSchool of Materials Engineering, Purdue University, West Lafayette, Indiana 47906, United States.ORCID 0000-0002-3283-7986
Joseph ValentiCollege of Agriculture, Health, and Natural Resources, University of Connecticut, Storrs, Connecticut 06269, United States.
Mukerrem CakmakSchool of Materials Engineering, Purdue University, West Lafayette, Indiana 47906, United States.ORCID 0000-0001-9128-7833
Lakshmi S NairThe Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health Center, Farmington, Connecticut 06030, United States.
Gregory A SotzingDepartment of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States.
University of Connecticut · USPurdue University West Lafayette · USUConn Health · US

Funding

Novel injectable analgesic delivery system for musculoskeletal pain managementR01AR075143 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI NAIR, LAKSHMI S · 2019 to 2023
$2.1M
NIAMS NIH HHS R01 AR075143
6 · The paper itself

Abstract

The legalization of hemp cultivation in the United States has caused the price of hemp-derived cannabinoids to decrease 10-fold within 2 years. Cannabidiol (CBD), one of many naturally occurring diols found in hemp, can be purified in high yield for low cost, making it an interesting candidate for polymer feedstock. In this study, two polyesters were synthesized from the condensation of either CBD or cannabigerol (CBG) with adipoyl chloride. Poly(CBD-Adipate) was cast into free-standing films and subjected to thermal, mechanical, and biological characterization. Poly(CBD-Adipate) films exhibited a lack of cytotoxicity toward adipose-derived stem cells while displaying an inherent antioxidant activity compared to poly(lactide) films. Additionally, this material was found to be semi-crystalline and able to be melt-processed into a plastic hemp leaf using a silicone baking mold.

Indexed as

CannabidiolCannabinoidsCannabisAdipatesAntioxidantsPlasticsPolyestersPolymersSiliconesAdipatesadipic acidAntioxidantsCannabidiolCannabinoidsPlasticsPolyestersPolymersSiliconesantioxidant materialscannabidiolmelt-processed polymerspolycannabinoidrenewable polymerswound healing

Identifiers

PMID36112124
PMCPMC10270313
OpenAlexW4296034725

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.