ArticleFrontiers in bioengineering and biotechnology2022
Adhesive, injectable, and ROS-responsive hybrid polyvinyl alcohol (PVA) hydrogel co-delivers metformin and fibroblast growth factor 21 (FGF21) for enhanced diabetic wound repair.
Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Topical metformin in wound healing: a comprehensive systematic review of therapeutic outcomes.Archives of dermatological research · 2025Pooled it
- How Transformative Are ROS Responsive Hydrogel Nanoformulations to Treat Refractory Infected Wounds.International journal of nanomedicine · 2026Review
- The Composite Antiadhesion Barrier Facilitated Fibroblast Autophagy Activation for Tendon Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Hydrogel-Based Treatment of Diabetic Wounds: From Smart Responsive to Smart Monitoring.Gels (Basel, Switzerland) · 2025Review
- Bioactive peptides and proteins for tissue repair: microenvironment modulation, rational delivery, and clinical potential.Military Medical Research · 2024Review
- Adhesive lipophilic gels delivering rapamycin prevent oral leukoplakia from malignant transformation.Materials today. Bio · 2024Article
- Advances in Smart-Response Hydrogels for Skin Wound Repair.Polymers · 2024Review
- The role of FGF-21 in promoting diabetic wound healing by modulating high glucose-induced inflammation.Heliyon · 2024Article
- Therapeutic Efficacy of Polymeric Biomaterials in Treating Diabetic Wounds-An Upcoming Wound Healing Technology.Polymers · 2023Review
- Effects of Metformin Delivery via Biomaterials on Bone and Dental Tissue Engineering.International journal of molecular sciences · 2022Review
- Metformin Enhances the Pro-Regenerative Function of Human Adipose-Derived Stromal Cells for Diabetic Wound Healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As conventional treatments for diabetic wounds often fail to achieve rapid satisfactory healing, the development of effective strategies to accelerate diabetic wound repair is highly demanded. Herein, fibroblast growth factor 21 (FGF21) and metformin co-loaded multifunctional polyvinyl alcohol (PVA) hydrogel were fabricated for improved diabetic wound healing. The
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.