Influencing factors of vision-threatening disease among patients with diabetes in the central region of Saudi Arabia: A case-control study.

Aims: Diabetic retinopathy is called as vision threatening disease. It affects retina very severely. DR is a common public health problem in Worldwide. Our main objective was to identify significant risk factors for diabetic retinopathy among diabetes mellitus patients. Materials and Methods: The present retrospective Case-Control study was conducted with 404 DM patients' records were collected from King Abdulaziz Medical City, Riyadh, Saudi Arabia. Statistical analysis used: Data were presented as descriptive statistics, multivariate logistic regression, association between variables was using odds ratio and 95% confidence interval. Results: Among 404 diabetes patients, 192 (47.5%) were Cases and 212 (52.5%) Controls. In multivariate regression analysis showed that male gender also had a higher likelihood in the development of DR, OR: 1. 68 [95% CI: (1.04 - 2.71); p<0.05]. Patients with poor glycaemic control, OR: 4. 86 [95% CI: (2.21-10.66); p<0.001]. Similarly, HbA1C, Low LDL was prominent risk factor in the progression of DR except age, hypocholesterolaemia, nephropathy wasn't significant. Conclusions: From our study findings, male gender, tobacco habit, poor glycaemic control, and Low HDL were appeared independently associated with the development of vision-threatening disease. By regular check-up, reducing risk factors or retain their stages in the same stage or to prolong the DR incidents among DM patients.