ReviewRSC advances2022
Recent progress in the chemistry of β-aminoketones.
Review in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 39 citations in OpenAlex.
- Synthesis and structure of (7aActa crystallographica. Section E, Crystallographic communications · 2026Article
- Photoredox/Nickel Dual-Catalyzed Asymmetric C-Alkylation of Nitroalkanes with α-Bromoketones.Organic letters · 2026Article
- Photocatalyzed hydrogen atom transfer enables multicomponent olefin oxo-amidomethylation under aerobic conditions.Chemical science · 2025Article
- Synthesis of Trifluoroacetamidoketones by Acylation of Ferrocene with In Situ Protected Amino Acids.The Journal of organic chemistry · 2025Article
- Interrogation of Enantioselectivity in the Photomediated Ring Contractions of Saturated Heterocycles.Journal of the American Chemical Society · 2025Article
- Addition of allyl Grignard to nitriles in air and at room temperature: experimental and computational mechanistic insights in pH-switchable synthesis.Chemical science · 2024Article
- Developments of pyridodipyrimidine heterocycles and their biological activities.Molecular diversity · 2024Review
- Synthesis, biological activities, and future perspectives of steroidal monocyclic pyridines.RSC medicinal chemistry · 2023Review
- Synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts.RSC advances · 2023Review
- Novel Siglec-15-Sia axis inhibitor leads to colorectal cancer cell death by targeting miR-6715b-3p and oncogenes.Frontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The β-aminoketone moiety has been found to be the basic skeleton of several drugs such as the amine salts "tolperisone (vasodilation)" and "oxyfedrine (therapeutic coronary disease)", and fluoroaryl derivatives such as "sitagliptin (antidiabetic)". The objective of this review is to summarize and highlight the chemistry of compounds reported with a β-aminoketone core in the last five years regarding their synthetic strategies, chemical reactivity, and mechanistic synthetic pathways. In the different sections, we categorize the synthesis of β-aminoketones by Mannich reactions
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.