Evidence map›Paper›PMID 36130461›Full record

ArticleRheumatology (Oxford, England)2023

Whole grain consumption and risk of radiographic knee osteoarthritis: a prospective study from the Osteoarthritis Initiative.

Tong Liu, Chang Xu, Jeffery B Driban, Ge-Yu Liang, Xue-Hong Zhang, Frank B Hu, Timothy McAlindon, Bing Lu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rheumatology (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Tong LiuDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0563-303X
Chang XuDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jeffery B DribanDivision of Rheumatology, Allergy, and Immunology, Tufts Medical Center, Boston, MA, USA.
Ge-Yu LiangKey Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu, China.
Xue-Hong ZhangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Frank B HuChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Timothy McAlindonDivision of Rheumatology, Allergy, and Immunology, Tufts Medical Center, Boston, MA, USA.
Bing LuDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Brigham and Women's Hospital · USTufts Medical Center · USRutgers, The State University of New Jersey · USSoutheast University · CN

Funding

DATA COORDINATING CENTER FOR THE OSTEOARTHRITIS INITIATIVEN01AR22258 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEVITT, MICHAEL · 2007 to 2011
$13.5M
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVEN01AR22259 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI HOCHBERG, MARC C. · 2007 to 2011
$7.8M
Clinical Centers for the Osteoarthritis Initiative^Rhode IslandN01AR22262 · NIAMS · MEMORIAL HOSPITAL OF RHODE ISLAND · PI EATON, CHARLES B. · 2007 to 2010
$6.8M
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVEN01AR22261 · NIAMS · OHIO STATE UNIVERSITY RESEARCH FDN · PI JACKSON, REBECCA · 2007 to 2011
$6.2M
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVEN01AR22260 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2007 to 2010
$6.1M
Metabolites of Dietary Intake and Risk of Knee OsteoarthritisR01AR074447 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LU, BING · 2019 to 2022
$2.6M
NEW PHARMACOLOGY ASPECTS RELATED TO CARBONIC ANHYDRASER01HL022258 · NHLBI · UNIVERSITY OF FLORIDA · PI MAREN, THOMAS H · 1985 to 1986
–
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22260N01AR022260 · NIAMS · UNIVERSITY OF PITTSBURGH · PI KWOH, KENT · 2002 to 2006
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CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22261N01AR022261 · NIAMS · OHIO STATE UNIVERSITY RESEARCH · PI JACKSON, REBECCA · 2002 to 2006
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CLINICAL CENTER FOR THE OSTEOARTHRITIS-264022262-264022262N01AR022262 · NIAMS · THE MEMORIAL HOSPITAL · PI ASSAF, ANNLOUISE R. · 2002 to 2006
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CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-264022259-264022259N01AR022259 · NIAMS · UNIVERSITY OF MARYLAND AT BALT · PI HOCHBERG, MARC C. · 2002 to 2006
–
NHLBI NIH HHS N01AR22258NIAMS NIH HHS N01AR22259NIAMS NIH HHS N01AR22260NIAMS NIH HHS N01AR22261NIAMS NIH HHS N01AR22262NIAMS NIH HHS R01 AR074447NIH HHS
6 · The paper itself

Abstract

objectivesTo assess the association of whole grain consumption with the risk of incident knee OA. MATERIAL AND

methodsWe followed 2846 participants in the Osteoarthritis Initiative ages 45-79 years. Participants were free from radiographic knee OA (Kellgren-Lawrence grade <2) in at least one knee at baseline. Dietary data from baseline were obtained using the Block Brief Food Frequency Questionnaire. We defined radiographic knee OA incidence as a Kellgren-Lawrence grade ≥2 during the subsequent 96 months. Cox proportional hazards models were used to assess the association between whole grain food intake and the risk of incident knee OA.

resultsDuring the 96 month follow-up, 518 participants (691 knees) developed incident radiographic knee OA. Higher total whole grain consumption was significantly associated with a lower knee OA risk [hazard ratio (HR)quartile 4vs1 = 0.66 (95% CI 0.52, 0.84), P for trend < 0.01] after adjusting for demographic and socio-economic factors, clinical factors and other dietary factors related to OA. Consistently, a significant inverse association of dark bread consumption with knee OA risk was observed [HRquartile 4vs1 = 0.68 (95% CI 0.53, 0.87), P for trend < 0.01). In addition, we observed a significant inverse association between higher cereal fibre intake and reduced knee OA risk [HRquartile 4vs1 = 0.61 (95% CI 0.46, 0.81), P for trend < 0.01).

conclusionsOur findings revealed a significant inverse association of whole grain consumption with knee OA risk. These findings provide evidence that eating a diet rich in whole grains may be a potential nutritional strategy to prevent knee OA.

Indexed as

Osteoarthritis, KneeAgedDietHumansKnee JointMiddle AgedProspective StudiesRisk FactorsWhole Grainsfibreknee OAprospective cohortriskwhole grain

Identifiers

PMID36130461
PMCPMC10152291
OpenAlexW4296932894

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.