ArticleThe European respiratory journal2023
Intrapulmonary shunt and alveolar dead space in a cohort of patients with acute COVID-19 pneumonitis and early recovery.
Article in The European respiratory journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Current Insights into Clinical, Molecular, and Therapeutic Approaches to Acute Respiratory Distress Syndrome.Medical sciences (Basel, Switzerland) · 2026Review
- Shunt estimation in pneumonia of different aetiologies: a non-invasive physiological assessment.BMJ open respiratory research · 2026Article
- Advances in gas-exchange physiology and pathophysiology.ERS monograph · 2025Article
- Contribution of intrapulmonary shunt to the pathogenesis of profound hypoxaemia in viral infection: a mechanistic discussion with an illustrative case.Journal of the Intensive Care Society · 2024Article
- Repercussions of SARS-CoV-2 infection on intrapulmonary shunt in patients undergoing one-lung ventilation.Journal of cardiothoracic surgery · 2024Article
- The role of vasculature and angiogenesis in respiratory diseases.Angiogenesis · 2024Review
- A mathematical model to assess the effects of COVID-19 on the cardiocirculatory system.Scientific reports · 2024Article
- Improved oxygenation in prone positioning of mechanically ventilated patients with COVID-19 acute respiratory distress syndrome is associated with decreased pulmonary shunt fraction: a prospective multicenter study.European journal of medical research · 2023Observational
- Increased intrapulmonary shunt and alveolar dead space post-COVID-19.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Sleep disturbances, dyspnoea, and anxiety in long COVID.The Lancet. Respiratory medicine · 2023Article
- Reply: Intrapulmonary shunt and alveolar dead space in a cohort of patients with acute COVID-19 pneumonitis and early recovery.The European respiratory journal · 2023Article
- Comment on: Intrapulmonary shunt and alveolar dead space in a cohort of patients with acute COVID-19 pneumonitis and early recovery.The European respiratory journal · 2023Article
- Novel gas exchange analysis in COVID-19 lung disease.The European respiratory journal · 2023Article
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundPathological evidence suggests that coronavirus disease 2019 (COVID-19) pulmonary infection involves both alveolar damage (causing shunt) and diffuse microvascular thrombus formation (causing alveolar dead space). We propose that measuring respiratory gas exchange enables detection and quantification of these abnormalities. We aimed to measure shunt and alveolar dead space in moderate COVID-19 during acute illness and recovery.
methodsWe studied 30 patients (22 males; mean±sd age 49.9±13.5 years) 3-15 days from symptom onset and again during recovery, 55±10 days later (n=17). Arterial blood (breathing ambient air) was collected while exhaled oxygen and carbon dioxide concentrations were measured, yielding alveolar-arterial differences for each gas (
resultsFor acute COVID-19 patients, group mean (range) for
conclusionsWe speculate impaired pulmonary gas exchange in early COVID-19 pneumonitis arises from two concurrent, independent and variable processes (alveolar filling and pulmonary vascular obstruction). For most patients these resolve within weeks; however, high alveolar dead space in ∼30% of recovered patients suggests persistent pulmonary vascular pathology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.