Evidence map›Paper›PMID 36139148›Full record

ArticleBiomolecules2022

6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist.

Peter Cuthbertson, Amal Elhage, Dena Al-Rifai, Reece A Sophocleous, Ross J Turner, Ashraf Aboelela, Hiwa Majed, Richard S Bujaroski, Iman Jalilian, Michael J Kelso and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Animal Models for the Investigation of P2X7 Receptors.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

Peter CuthbertsonIllawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.ORCID 0000-0003-2903-2586
Amal ElhageIllawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
Dena Al-RifaiIllawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
Reece A SophocleousIllawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
Ross J TurnerIllawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
Ashraf AboelelaIllawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
Hiwa MajedIllawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
Richard S BujaroskiIllawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.ORCID 0000-0002-8459-527X
Iman JalilianIllawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
Michael J KelsoIllawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.ORCID 0000-0001-7809-6637
Debbie WatsonIllawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.
Benjamin J BuckleyIllawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.ORCID 0000-0002-8346-3371
Ronald SluyterIllawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.ORCID 0000-0003-4909-686X
University of Wollongong · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

P2X7 is an extracellular adenosine 5'-triphopshate (ATP)-gated cation channel present on leukocytes, where its activation induces pro-inflammatory cytokine release and ectodomain shedding of cell surface molecules. Human P2X7 can be partially inhibited by amiloride and its derivatives at micromolar concentrations. This study aimed to screen a library of compounds derived from amiloride or its derivative 5-(

Indexed as

Purinergic P2X Receptor AntagonistsReceptors, Purinergic P2X7AdenosineAdenosine TriphosphateAmilorideAnimalsDogsHEK293 CellsHumansInterleukin-1betaMice5-(N,N-hexamethylene)amilorideAdenosineAdenosine TriphosphateAmilorideInterleukin-1betaPurinergic P2X Receptor AntagonistsReceptors, Purinergic P2X7amilorideB cellinterleukin-1βlow affinity IgE receptormonocyteP2X4 receptorP2X7 receptorP2Y receptorpurinergic signallingT cell

Identifiers

PMID36139148
PMCPMC9496321
OpenAlexW4296252930

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.