Evidence map›Paper›PMID 36139151›Full record

Trial reportBiomolecules2022

Effects of RIPC on the Metabolome in Patients Undergoing Vascular Surgery: A Randomized Controlled Trial.

Kadri Eerik, Teele Kasepalu, Karl Kuusik, Jaan Eha, Mare Vähi, Kalle Kilk, Mihkel Zilmer, Jaak Kals

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Interplay between ischemia-reperfusion and metabolic reprogramming.Apoptosis : an international journal on programmed cell death · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kadri EerikEndothelial Research Centre, University of Tartu, 8 Puusepa Street, 51014 Tartu, Estonia.ORCID 0000-0002-0101-2228
Teele KasepaluEndothelial Research Centre, University of Tartu, 8 Puusepa Street, 51014 Tartu, Estonia.
Karl KuusikEndothelial Research Centre, University of Tartu, 8 Puusepa Street, 51014 Tartu, Estonia.
Jaan EhaEndothelial Research Centre, University of Tartu, 8 Puusepa Street, 51014 Tartu, Estonia.
Mare VähiInstitute of Mathematics and Statistics, University of Tartu, 18 Narva mnt. Street, 51009 Tartu, Estonia.
Kalle KilkDepartment of Biochemistry, Institute of Biomedicine and Translational Medicine, Centre of Excellence for Genomics and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.ORCID 0000-0003-4551-9466
Mihkel ZilmerEndothelial Research Centre, University of Tartu, 8 Puusepa Street, 51014 Tartu, Estonia.
Jaak KalsEndothelial Research Centre, University of Tartu, 8 Puusepa Street, 51014 Tartu, Estonia.ORCID 0000-0002-8745-718X
Tartu University Hospital · EEUniversity of Tartu · EE

Funding

ENDOCRINE FACTORS AND SEXUALITY IN AGINGR01AG001437 · NIA · STANFORD UNIVERSITY · PI DAVIDSON, JULIAN M. · 1985 to 1986
–
PHARMACOLOGIC FACTORS &SEXUALITY IN AGING HYPERTENSIONR37AG001437 · NIA · STANFORD UNIVERSITY · PI HOFFMAN, BRIAN B · 1988 to 1992
–
6 · The paper itself

Abstract

backgroundremote ischemic preconditioning (RIPC) is a phenomenon in which short episodes of ischemia are applied to distant organs to prepare target organs for more prolonged ischemia and to induce protection against ischemia-reperfusion injury. This study aims to evaluate whether preoperatively performed RIPC affects the metabolome and to assess whether metabolomic changes correlate with heart and kidney injury markers after vascular surgery.

methodsa randomized sham-controlled, double-blinded trial was conducted at Tartu University Hospital. Patients undergoing elective open vascular surgery were recruited and RIPC was applied before operation. Blood was collected preoperatively and 24 h postoperatively. The metabolome was analyzed using the AbsoluteIDQ p180 Kit.

resultsfinal analysis included 45 patients from the RIPC group and 47 from the sham group. RIPC did not significantly alter metabolites 24 h postoperatively. There was positive correlation of change in the kynurenine/tryptophan ratio with change in hs-troponin T (

conclusionspreoperative RIPC did not significantly affect the metabolome 24 h after vascular surgery. The positive linear correlation of kynurenine/tryptophan ratio with heart and kidney injury markers suggests that the kynurenine-tryptophan pathway can play a role in RIPC-associated cardio- and nephroprotective effects.

Indexed as

Ischemic PreconditioningVascular Surgical ProceduresBiomarkersCystatin CHumansKynurenineMetabolomeTroponin TTryptophanBiomarkersCystatin CKynurenineTroponin TTryptophanmetabolomicsremote ischemic preconditioningvascular surgery

Identifiers

PMID36139151
PMCPMC9496371
OpenAlexW4296251811

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.