ArticleCancers2022
Cachexia Index as a Prognostic Indicator in Patients with Gastric Cancer: A Retrospective Study.
Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Systemic Inflammatory Biomarkers and Cancer-Associated Cachexia: A Narrative Review.Current oncology (Toronto, Ont.) · 2026Review
- Prognostic Impact of Cachexia Index in Patients Undergoing Surgery for Esophageal Cancer.Annals of surgical oncology · 2026Article
- Symptom Burden and Healthcare Resource Use in Patients With Claudin 18.2-Positive, HER2-Negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma: A Retrospective Review.Clinical Medicine Insights. Oncology · 2026Article
- The prognostic value of cachexia index in patients with lung cancer treated with immune checkpoint inhibitors: a propensity score matching analysis.Frontiers in nutrition · 2026Article
- Article
- Low Preoperative Cachexia Index Is Associated with Severe Postoperative Morbidity in Patients Undergoing Gastrectomy for Gastric Cancer.Diagnostics (Basel, Switzerland) · 2025Article
- Clinical significance of cachexia index determined by bioelectrical impedance analysis in patients with gastrointestinal cancer.Oncology letters · 2025Article
- Developing and validating a Modified Cachexia Index to predict the outcomes for colorectal cancer after radical surgery.European journal of clinical nutrition · 2024Article
- CT-determined low skeletal muscle index predicts poor prognosis in patients with colorectal cancer.Cancer medicine · 2024Article
- Cachexia index for prognostication in surgical patients with locally advanced oesophageal or gastric cancer: multicentre cohort study.The British journal of surgery · 2024Article
- The Utility of the Cachexia Index and the Modified Glasgow Score in Young Patients With Breast Cancer.Cureus · 2024Article
- Comparison of the cachexia index based on hand-grip strength (H-CXI) with the original CXI for the prediction of cancer cachexia and prognosis in patients who underwent radical colectomy for colorectal cancer.Frontiers in nutrition · 2024Article
- Prognostic Significance of the Cachexia Index in Patients with Non-Small-Cell Lung Cancer and Brain Metastases after Stereotactic Radiotherapy.Clinical Medicine Insights. Oncology · 2024Article
- Comment on 'Hand grip strength-based cachexia index as a predictor of cancer cachexia and prognosis in patients with cancer' by Xie et al.Journal of cachexia, sarcopenia and muscle · 2023Article
- Nutritional risk index predicts the prognosis of gastric cancer patients with pyloric stenosis who received preoperative parenteral nutrition.Oncology letters · 2023Article
- Editorial: Immunology of cachexia.Frontiers in immunology · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The current diagnostic criteria for cancer cachexia are inconsistent, and the prognostic value of cachexia in gastric cancer (GC) is controversial. This study aimed to investigate the prognostic value of the cachexia index (CXI) in patients with GC. We calculated the CXI as skeletal muscle index (SMI) × serum albumin/neutrophil-lymphocyte ratio (NLR), and a total of 161 and 163 patients were included in the high and low CXI groups, respectively. Low CXI was significantly associated with a more advanced tumor−node−metastasis (TNM) stage, a higher level of serum C-reactive protein, serum interleukin-6, and NLR, but also a decreased level of serum prealbumin and albumin. In addition, patients in the low CXI group were more likely to have postoperative pulmonary infections (9.8% vs. 3.7%, p = 0.03). Cox proportional analyses indicated that patients with low CXI (HR 0.45, 95% CI 0.29 to 0.69; p < 0.001) or TNM stage III+IV (HR 4.38, 95% CI 2.54 to 7.55; p < 0.001) had a significantly poorer overall survival (OS). Kaplan−Meier survival curves suggested that patients with low CXI had a significantly decreased OS, which was not affected by subgroup analyses of different sex, age, cachexia, body mass index (BMI), and TNM stage. Furthermore, low CXI combined with cachexia, low BMI, or TNM stage III+IV caused the worst OS in each subgroup analysis, respectively. Our study demonstrated that CXI had a good prognostic value in GC. Greater attention should be paid to patients with low CXI, particularly those combined with cachexia, low BMI, or TNM stage III+IV.
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